Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A0A381ML15_LEIIN

TriTrypDb:

LINF_270020800

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A381ML15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381ML15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.611
CLV_NRD_NRD_1	315	317	PF00675	0.649
CLV_NRD_NRD_1	395	397	PF00675	0.677
CLV_NRD_NRD_1	907	909	PF00675	0.530
CLV_PCSK_KEX2_1	270	272	PF00082	0.698
CLV_PCSK_KEX2_1	278	280	PF00082	0.609
CLV_PCSK_KEX2_1	315	317	PF00082	0.589
CLV_PCSK_KEX2_1	397	399	PF00082	0.738
CLV_PCSK_KEX2_1	907	909	PF00082	0.530
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.613
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.672
CLV_PCSK_PC7_1	266	272	PF00082	0.571
CLV_PCSK_PC7_1	393	399	PF00082	0.745
CLV_PCSK_SKI1_1	241	245	PF00082	0.559
CLV_PCSK_SKI1_1	278	282	PF00082	0.634
CLV_PCSK_SKI1_1	315	319	PF00082	0.623
CLV_PCSK_SKI1_1	424	428	PF00082	0.478
CLV_PCSK_SKI1_1	512	516	PF00082	0.529
CLV_PCSK_SKI1_1	74	78	PF00082	0.453
CLV_PCSK_SKI1_1	86	90	PF00082	0.478
CLV_PCSK_SKI1_1	908	912	PF00082	0.530
DEG_APCC_DBOX_1	171	179	PF00400	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DEG_SPOP_SBC_1	300	304	PF00917	0.576
DEG_SPOP_SBC_1	521	525	PF00917	0.628
DEG_SPOP_SBC_1	611	615	PF00917	0.539
DOC_CYCLIN_RxL_1	275	283	PF00134	0.605
DOC_CYCLIN_RxL_1	312	321	PF00134	0.620
DOC_MAPK_gen_1	117	126	PF00069	0.431
DOC_MAPK_gen_1	54	63	PF00069	0.508
DOC_MAPK_gen_1	684	693	PF00069	0.577
DOC_MAPK_MEF2A_6	119	128	PF00069	0.521
DOC_MAPK_MEF2A_6	54	63	PF00069	0.508
DOC_MAPK_MEF2A_6	755	763	PF00069	0.502
DOC_MAPK_MEF2A_6	90	97	PF00069	0.465
DOC_PP1_RVXF_1	232	238	PF00149	0.465
DOC_PP1_RVXF_1	797	804	PF00149	0.522
DOC_PP2B_LxvP_1	297	300	PF13499	0.632
DOC_PP4_FxxP_1	281	284	PF00568	0.623
DOC_PP4_FxxP_1	346	349	PF00568	0.492
DOC_USP7_MATH_1	111	115	PF00917	0.531
DOC_USP7_MATH_1	220	224	PF00917	0.583
DOC_USP7_MATH_1	258	262	PF00917	0.657
DOC_USP7_MATH_1	29	33	PF00917	0.422
DOC_USP7_MATH_1	399	403	PF00917	0.687
DOC_USP7_MATH_1	422	426	PF00917	0.426
DOC_USP7_MATH_1	43	47	PF00917	0.598
DOC_USP7_MATH_1	468	472	PF00917	0.453
DOC_USP7_MATH_1	479	483	PF00917	0.521
DOC_USP7_MATH_1	52	56	PF00917	0.763
DOC_USP7_MATH_1	522	526	PF00917	0.661
DOC_USP7_MATH_1	552	556	PF00917	0.632
DOC_USP7_MATH_1	610	614	PF00917	0.647
DOC_USP7_MATH_1	655	659	PF00917	0.580
DOC_USP7_MATH_1	811	815	PF00917	0.603
DOC_USP7_MATH_1	818	822	PF00917	0.573
DOC_USP7_MATH_1	851	855	PF00917	0.681
DOC_USP7_MATH_1	859	863	PF00917	0.645
DOC_WW_Pin1_4	102	107	PF00397	0.472
DOC_WW_Pin1_4	256	261	PF00397	0.610
DOC_WW_Pin1_4	280	285	PF00397	0.773
DOC_WW_Pin1_4	3	8	PF00397	0.436
DOC_WW_Pin1_4	356	361	PF00397	0.518
DOC_WW_Pin1_4	492	497	PF00397	0.545
DOC_WW_Pin1_4	542	547	PF00397	0.571
DOC_WW_Pin1_4	606	611	PF00397	0.600
DOC_WW_Pin1_4	612	617	PF00397	0.577
DOC_WW_Pin1_4	64	69	PF00397	0.447
DOC_WW_Pin1_4	650	655	PF00397	0.533
DOC_WW_Pin1_4	841	846	PF00397	0.644
LIG_14-3-3_CanoR_1	241	248	PF00244	0.551
LIG_14-3-3_CanoR_1	28	38	PF00244	0.364
LIG_14-3-3_CanoR_1	398	407	PF00244	0.687
LIG_14-3-3_CanoR_1	472	478	PF00244	0.657
LIG_14-3-3_CanoR_1	54	60	PF00244	0.545
LIG_14-3-3_CanoR_1	567	573	PF00244	0.706
LIG_14-3-3_CanoR_1	585	593	PF00244	0.426
LIG_14-3-3_CanoR_1	743	749	PF00244	0.541
LIG_14-3-3_CanoR_1	780	789	PF00244	0.592
LIG_14-3-3_CanoR_1	802	810	PF00244	0.606
LIG_14-3-3_CanoR_1	892	901	PF00244	0.559
LIG_Actin_WH2_2	671	688	PF00022	0.596
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.550
LIG_BIR_III_4	383	387	PF00653	0.591
LIG_BRCT_BRCA1_1	104	108	PF00533	0.430
LIG_BRCT_BRCA1_1	26	30	PF00533	0.433
LIG_BRCT_BRCA1_1	482	486	PF00533	0.775
LIG_BRCT_BRCA1_1	5	9	PF00533	0.423
LIG_BRCT_BRCA1_1	678	682	PF00533	0.601
LIG_BRCT_BRCA1_2	678	684	PF00533	0.607
LIG_FHA_1	125	131	PF00498	0.336
LIG_FHA_1	210	216	PF00498	0.561
LIG_FHA_1	275	281	PF00498	0.689
LIG_FHA_1	496	502	PF00498	0.429
LIG_FHA_1	532	538	PF00498	0.486
LIG_FHA_1	58	64	PF00498	0.557
LIG_FHA_1	647	653	PF00498	0.569
LIG_FHA_1	793	799	PF00498	0.549
LIG_FHA_1	900	906	PF00498	0.519
LIG_FHA_2	172	178	PF00498	0.628
LIG_FHA_2	439	445	PF00498	0.537
LIG_FHA_2	569	575	PF00498	0.571
LIG_FHA_2	696	702	PF00498	0.578
LIG_GBD_Chelix_1	905	913	PF00786	0.577
LIG_IRF3_LxIS_1	59	66	PF10401	0.307
LIG_LIR_Gen_1	250	260	PF02991	0.614
LIG_LIR_Gen_1	288	297	PF02991	0.613
LIG_LIR_Gen_1	335	346	PF02991	0.414
LIG_LIR_Gen_1	361	372	PF02991	0.399
LIG_LIR_Nem_3	250	256	PF02991	0.605
LIG_LIR_Nem_3	288	292	PF02991	0.601
LIG_LIR_Nem_3	335	341	PF02991	0.446
LIG_LIR_Nem_3	361	367	PF02991	0.392
LIG_LIR_Nem_3	571	575	PF02991	0.517
LIG_LIR_Nem_3	591	596	PF02991	0.377
LIG_LIR_Nem_3	668	674	PF02991	0.503
LIG_LIR_Nem_3	679	685	PF02991	0.543
LIG_LIR_Nem_3	89	95	PF02991	0.492
LIG_MLH1_MIPbox_1	5	9	PF16413	0.423
LIG_PCNA_yPIPBox_3	231	243	PF02747	0.536
LIG_PDZ_Class_3	909	914	PF00595	0.567
LIG_SH2_CRK	338	342	PF00017	0.391
LIG_SH2_CRK	671	675	PF00017	0.569
LIG_SH2_PTP2	340	343	PF00017	0.378
LIG_SH2_SRC	338	341	PF00017	0.382
LIG_SH2_STAP1	191	195	PF00017	0.592
LIG_SH2_STAP1	338	342	PF00017	0.383
LIG_SH2_STAP1	497	501	PF00017	0.524
LIG_SH2_STAP1	597	601	PF00017	0.532
LIG_SH2_STAT3	507	510	PF00017	0.439
LIG_SH2_STAT3	540	543	PF00017	0.598
LIG_SH2_STAT5	100	103	PF00017	0.416
LIG_SH2_STAT5	340	343	PF00017	0.383
LIG_SH2_STAT5	345	348	PF00017	0.471
LIG_SH2_STAT5	464	467	PF00017	0.509
LIG_SH2_STAT5	497	500	PF00017	0.440
LIG_SH2_STAT5	507	510	PF00017	0.339
LIG_SH3_1	475	481	PF00018	0.619
LIG_SH3_3	216	222	PF00018	0.550
LIG_SH3_3	254	260	PF00018	0.697
LIG_SH3_3	281	287	PF00018	0.585
LIG_SH3_3	475	481	PF00018	0.619
LIG_SH3_3	688	694	PF00018	0.550
LIG_SH3_3	826	832	PF00018	0.818
LIG_SH3_3	842	848	PF00018	0.626
LIG_Sin3_3	638	645	PF02671	0.596
LIG_SUMO_SIM_anti_2	498	505	PF11976	0.453
LIG_SUMO_SIM_anti_2	574	582	PF11976	0.536
LIG_SUMO_SIM_par_1	865	872	PF11976	0.443
LIG_TRAF2_1	227	230	PF00917	0.500
LIG_TRAF2_1	411	414	PF00917	0.621
LIG_WRC_WIRS_1	363	368	PF05994	0.468
MOD_CDC14_SPxK_1	283	286	PF00782	0.587
MOD_CDK_SPK_2	612	617	PF00069	0.553
MOD_CDK_SPxK_1	280	286	PF00069	0.592
MOD_CK1_1	210	216	PF00069	0.619
MOD_CK1_1	259	265	PF00069	0.632
MOD_CK1_1	358	364	PF00069	0.490
MOD_CK1_1	365	371	PF00069	0.424
MOD_CK1_1	495	501	PF00069	0.588
MOD_CK1_1	513	519	PF00069	0.637
MOD_CK1_1	525	531	PF00069	0.541
MOD_CK1_1	55	61	PF00069	0.531
MOD_CK1_1	627	633	PF00069	0.621
MOD_CK1_1	841	847	PF00069	0.574
MOD_CK2_1	409	415	PF00069	0.670
MOD_CK2_1	438	444	PF00069	0.537
MOD_CMANNOS	137	140	PF00535	0.465
MOD_GlcNHglycan	112	116	PF01048	0.572
MOD_GlcNHglycan	132	135	PF01048	0.319
MOD_GlcNHglycan	203	206	PF01048	0.727
MOD_GlcNHglycan	207	210	PF01048	0.688
MOD_GlcNHglycan	266	269	PF01048	0.690
MOD_GlcNHglycan	297	300	PF01048	0.739
MOD_GlcNHglycan	31	34	PF01048	0.524
MOD_GlcNHglycan	378	381	PF01048	0.496
MOD_GlcNHglycan	401	404	PF01048	0.730
MOD_GlcNHglycan	512	515	PF01048	0.593
MOD_GlcNHglycan	524	527	PF01048	0.613
MOD_GlcNHglycan	554	557	PF01048	0.583
MOD_GlcNHglycan	627	630	PF01048	0.593
MOD_GlcNHglycan	724	727	PF01048	0.606
MOD_GlcNHglycan	784	787	PF01048	0.559
MOD_GlcNHglycan	804	807	PF01048	0.402
MOD_GlcNHglycan	820	823	PF01048	0.540
MOD_GlcNHglycan	840	843	PF01048	0.544
MOD_GlcNHglycan	853	856	PF01048	0.691
MOD_GlcNHglycan	861	864	PF01048	0.747
MOD_GSK3_1	201	208	PF00069	0.636
MOD_GSK3_1	210	217	PF00069	0.530
MOD_GSK3_1	295	302	PF00069	0.683
MOD_GSK3_1	304	311	PF00069	0.615
MOD_GSK3_1	351	358	PF00069	0.586
MOD_GSK3_1	480	487	PF00069	0.633
MOD_GSK3_1	521	528	PF00069	0.661
MOD_GSK3_1	606	613	PF00069	0.625
MOD_GSK3_1	64	71	PF00069	0.424
MOD_GSK3_1	646	653	PF00069	0.564
MOD_GSK3_1	672	679	PF00069	0.524
MOD_GSK3_1	718	725	PF00069	0.620
MOD_GSK3_1	895	902	PF00069	0.616
MOD_N-GLC_1	561	566	PF02516	0.542
MOD_N-GLC_1	721	726	PF02516	0.620
MOD_N-GLC_2	35	37	PF02516	0.473
MOD_NEK2_1	124	129	PF00069	0.427
MOD_NEK2_1	16	21	PF00069	0.475
MOD_NEK2_1	171	176	PF00069	0.627
MOD_NEK2_1	190	195	PF00069	0.454
MOD_NEK2_1	24	29	PF00069	0.372
MOD_NEK2_1	376	381	PF00069	0.529
MOD_NEK2_1	454	459	PF00069	0.430
MOD_NEK2_1	515	520	PF00069	0.576
MOD_NEK2_1	63	68	PF00069	0.367
MOD_NEK2_1	674	679	PF00069	0.583
MOD_NEK2_1	70	75	PF00069	0.494
MOD_NEK2_1	744	749	PF00069	0.479
MOD_NEK2_1	782	787	PF00069	0.500
MOD_NEK2_1	804	809	PF00069	0.562
MOD_NEK2_1	880	885	PF00069	0.586
MOD_PIKK_1	301	307	PF00454	0.585
MOD_PIKK_1	554	560	PF00454	0.497
MOD_PIKK_1	646	652	PF00454	0.602
MOD_PIKK_1	655	661	PF00454	0.489
MOD_PKA_2	171	177	PF00069	0.553
MOD_PKA_2	285	291	PF00069	0.612
MOD_PKA_2	399	405	PF00069	0.832
MOD_PKA_2	55	61	PF00069	0.514
MOD_PKA_2	579	585	PF00069	0.511
MOD_PKA_2	718	724	PF00069	0.600
MOD_PKA_2	744	750	PF00069	0.462
MOD_PKA_2	782	788	PF00069	0.504
MOD_Plk_1	191	197	PF00069	0.592
MOD_Plk_1	210	216	PF00069	0.611
MOD_Plk_1	561	567	PF00069	0.544
MOD_Plk_2-3	173	179	PF00069	0.563
MOD_Plk_4	136	142	PF00069	0.507
MOD_Plk_4	308	314	PF00069	0.677
MOD_Plk_4	497	503	PF00069	0.440
MOD_Plk_4	574	580	PF00069	0.537
MOD_Plk_4	895	901	PF00069	0.619
MOD_ProDKin_1	102	108	PF00069	0.467
MOD_ProDKin_1	256	262	PF00069	0.613
MOD_ProDKin_1	280	286	PF00069	0.773
MOD_ProDKin_1	3	9	PF00069	0.433
MOD_ProDKin_1	356	362	PF00069	0.505
MOD_ProDKin_1	492	498	PF00069	0.540
MOD_ProDKin_1	542	548	PF00069	0.573
MOD_ProDKin_1	606	612	PF00069	0.605
MOD_ProDKin_1	64	70	PF00069	0.455
MOD_ProDKin_1	650	656	PF00069	0.529
MOD_ProDKin_1	841	847	PF00069	0.644
MOD_SUMO_rev_2	223	233	PF00179	0.524
MOD_SUMO_rev_2	706	715	PF00179	0.543
TRG_DiLeu_BaEn_1	326	331	PF01217	0.403
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.631
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.353
TRG_DiLeu_BaLyEn_6	659	664	PF01217	0.509
TRG_ENDOCYTIC_2	338	341	PF00928	0.429
TRG_ENDOCYTIC_2	671	674	PF00928	0.564
TRG_ER_diArg_1	278	280	PF00400	0.615
TRG_ER_diArg_1	314	316	PF00400	0.691
TRG_ER_diArg_1	395	398	PF00400	0.669
TRG_ER_diArg_1	907	909	PF00400	0.530
TRG_NES_CRM1_1	238	250	PF08389	0.567
TRG_NLS_MonoCore_2	396	401	PF00514	0.783
TRG_NLS_MonoExtC_3	395	400	PF00514	0.804
TRG_NLS_MonoExtN_4	393	400	PF00514	0.850
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWA8	Leptomonas seymouri	48%	98%
A0A3S7X0S0	Leishmania donovani	99%	100%
A4HFR9	Leishmania braziliensis	72%	100%
D0A612	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9ADC4	Leishmania major	89%	99%
E9AZ48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%