Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A0A381MKM4_LEIIN

TriTrypDb:

LINF_270007100

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A381MKM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MKM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.554
CLV_NRD_NRD_1	159	161	PF00675	0.499
CLV_NRD_NRD_1	178	180	PF00675	0.380
CLV_NRD_NRD_1	281	283	PF00675	0.587
CLV_NRD_NRD_1	293	295	PF00675	0.391
CLV_NRD_NRD_1	74	76	PF00675	0.472
CLV_NRD_NRD_1	83	85	PF00675	0.420
CLV_PCSK_KEX2_1	159	161	PF00082	0.449
CLV_PCSK_KEX2_1	177	179	PF00082	0.388
CLV_PCSK_KEX2_1	20	22	PF00082	0.461
CLV_PCSK_KEX2_1	280	282	PF00082	0.597
CLV_PCSK_KEX2_1	293	295	PF00082	0.340
CLV_PCSK_KEX2_1	83	85	PF00082	0.459
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.537
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.475
CLV_PCSK_PC7_1	173	179	PF00082	0.462
CLV_PCSK_SKI1_1	116	120	PF00082	0.523
CLV_PCSK_SKI1_1	189	193	PF00082	0.462
CLV_PCSK_SKI1_1	20	24	PF00082	0.348
CLV_PCSK_SKI1_1	202	206	PF00082	0.348
CLV_PCSK_SKI1_1	301	305	PF00082	0.453
CLV_PCSK_SKI1_1	75	79	PF00082	0.517
DEG_APCC_DBOX_1	115	123	PF00400	0.579
DEG_APCC_DBOX_1	74	82	PF00400	0.486
DOC_CDC14_PxL_1	128	136	PF14671	0.484
DOC_CYCLIN_RxL_1	17	27	PF00134	0.415
DOC_CYCLIN_RxL_1	73	82	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.433
DOC_MAPK_gen_1	159	167	PF00069	0.510
DOC_MAPK_gen_1	184	193	PF00069	0.563
DOC_MAPK_gen_1	75	81	PF00069	0.460
DOC_MAPK_gen_1	83	89	PF00069	0.420
DOC_MAPK_MEF2A_6	43	51	PF00069	0.486
DOC_PP1_RVXF_1	74	81	PF00149	0.515
DOC_PP2B_LxvP_1	204	207	PF13499	0.478
DOC_PP4_FxxP_1	141	144	PF00568	0.556
DOC_USP7_MATH_1	10	14	PF00917	0.476
DOC_USP7_MATH_1	142	146	PF00917	0.483
DOC_USP7_MATH_1	245	249	PF00917	0.581
DOC_USP7_MATH_1	52	56	PF00917	0.538
DOC_USP7_MATH_1	70	74	PF00917	0.274
DOC_WW_Pin1_4	222	227	PF00397	0.504
DOC_WW_Pin1_4	29	34	PF00397	0.526
DOC_WW_Pin1_4	43	48	PF00397	0.315
LIG_14-3-3_CanoR_1	147	156	PF00244	0.505
LIG_14-3-3_CanoR_1	178	187	PF00244	0.530
LIG_BIR_III_2	255	259	PF00653	0.531
LIG_Clathr_ClatBox_1	310	314	PF01394	0.584
LIG_EVH1_1	128	132	PF00568	0.471
LIG_FHA_1	285	291	PF00498	0.522
LIG_FHA_1	298	304	PF00498	0.432
LIG_FHA_1	305	311	PF00498	0.473
LIG_FHA_2	222	228	PF00498	0.574
LIG_Integrin_RGD_1	63	65	PF01839	0.500
LIG_LIR_Gen_1	166	176	PF02991	0.495
LIG_LIR_Gen_1	265	275	PF02991	0.384
LIG_LIR_Nem_3	125	131	PF02991	0.489
LIG_LIR_Nem_3	166	172	PF02991	0.489
LIG_LIR_Nem_3	265	270	PF02991	0.337
LIG_LYPXL_S_1	127	131	PF13949	0.510
LIG_LYPXL_yS_3	128	131	PF13949	0.498
LIG_MAD2	294	302	PF02301	0.509
LIG_MYND_1	232	236	PF01753	0.376
LIG_Pex14_1	96	100	PF04695	0.420
LIG_PTAP_UEV_1	211	216	PF05743	0.543
LIG_PTB_Apo_2	47	54	PF02174	0.484
LIG_PTB_Phospho_1	47	53	PF10480	0.476
LIG_SH2_CRK	169	173	PF00017	0.508
LIG_SH2_CRK	53	57	PF00017	0.529
LIG_SH2_NCK_1	53	57	PF00017	0.529
LIG_SH2_STAT3	104	107	PF00017	0.510
LIG_SH2_STAT5	175	178	PF00017	0.326
LIG_SH3_3	124	130	PF00018	0.425
LIG_SH3_3	209	215	PF00018	0.481
LIG_SH3_3	223	229	PF00018	0.450
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.556
LIG_TYR_ITIM	167	172	PF00017	0.527
LIG_TYR_ITIM	51	56	PF00017	0.528
LIG_WW_2	129	132	PF00397	0.479
MOD_CK1_1	265	271	PF00069	0.412
MOD_CK1_1	276	282	PF00069	0.564
MOD_CK2_1	147	153	PF00069	0.465
MOD_CK2_1	245	251	PF00069	0.622
MOD_GlcNHglycan	12	15	PF01048	0.492
MOD_GlcNHglycan	149	152	PF01048	0.541
MOD_GlcNHglycan	211	215	PF01048	0.500
MOD_GlcNHglycan	260	263	PF01048	0.534
MOD_GSK3_1	142	149	PF00069	0.468
MOD_GSK3_1	258	265	PF00069	0.516
MOD_GSK3_1	269	276	PF00069	0.481
MOD_N-GLC_1	262	267	PF02516	0.410
MOD_NEK2_1	122	127	PF00069	0.463
MOD_NEK2_1	146	151	PF00069	0.468
MOD_NEK2_1	165	170	PF00069	0.418
MOD_NEK2_1	221	226	PF00069	0.594
MOD_NEK2_1	274	279	PF00069	0.560
MOD_NEK2_1	79	84	PF00069	0.519
MOD_NEK2_2	262	267	PF00069	0.465
MOD_NEK2_2	52	57	PF00069	0.528
MOD_OFUCOSY	264	269	PF10250	0.391
MOD_PKA_2	146	152	PF00069	0.473
MOD_PKA_2	185	191	PF00069	0.571
MOD_Plk_1	165	171	PF00069	0.497
MOD_Plk_1	262	268	PF00069	0.407
MOD_Plk_4	123	129	PF00069	0.464
MOD_Plk_4	167	173	PF00069	0.487
MOD_Plk_4	230	236	PF00069	0.379
MOD_Plk_4	262	268	PF00069	0.462
MOD_Plk_4	52	58	PF00069	0.513
MOD_Plk_4	91	97	PF00069	0.419
MOD_ProDKin_1	222	228	PF00069	0.495
MOD_ProDKin_1	29	35	PF00069	0.522
MOD_ProDKin_1	43	49	PF00069	0.307
TRG_DiLeu_BaEn_1	217	222	PF01217	0.541
TRG_DiLeu_BaEn_1	305	310	PF01217	0.467
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.490
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.527
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.498
TRG_ENDOCYTIC_2	128	131	PF00928	0.476
TRG_ENDOCYTIC_2	169	172	PF00928	0.500
TRG_ENDOCYTIC_2	53	56	PF00928	0.533
TRG_ER_diArg_1	159	161	PF00400	0.502
TRG_ER_diArg_1	280	282	PF00400	0.596
TRG_ER_diArg_1	293	295	PF00400	0.342
TRG_ER_diArg_1	83	86	PF00400	0.473
TRG_NLS_Bipartite_1	159	181	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E8	Leptomonas seymouri	62%	100%
A0A0S4IST0	Bodo saltans	29%	91%
A0A1X0NLN1	Trypanosomatidae	39%	92%
A0A3S7X0D1	Leishmania donovani	99%	100%
A0A422NXN0	Trypanosoma rangeli	40%	94%
A4HFE0	Leishmania braziliensis	84%	100%
C9ZKW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9ACZ9	Leishmania major	94%	100%
E9AYS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BBP3	Trypanosoma cruzi	39%	94%