LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A0A381MHF5_LEIIN
TriTrypDb:
LINF_220013000
Length:
302

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A381MHF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MHF5

PDB structure(s): 7ane_an

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003677 DNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 150 152 PF00675 0.624
CLV_NRD_NRD_1 186 188 PF00675 0.531
CLV_NRD_NRD_1 20 22 PF00675 0.392
CLV_NRD_NRD_1 250 252 PF00675 0.471
CLV_NRD_NRD_1 5 7 PF00675 0.392
CLV_PCSK_KEX2_1 150 152 PF00082 0.624
CLV_PCSK_KEX2_1 185 187 PF00082 0.547
CLV_PCSK_KEX2_1 20 22 PF00082 0.392
CLV_PCSK_KEX2_1 5 7 PF00082 0.392
CLV_PCSK_KEX2_1 71 73 PF00082 0.439
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.439
CLV_PCSK_SKI1_1 115 119 PF00082 0.399
CLV_PCSK_SKI1_1 12 16 PF00082 0.384
CLV_PCSK_SKI1_1 89 93 PF00082 0.566
DEG_Nend_UBRbox_2 1 3 PF02207 0.432
DEG_SCF_FBW7_2 240 246 PF00400 0.469
DOC_CKS1_1 240 245 PF01111 0.475
DOC_CKS1_1 63 68 PF01111 0.386
DOC_CYCLIN_RxL_1 228 236 PF00134 0.586
DOC_CYCLIN_yCln2_LP_2 237 243 PF00134 0.426
DOC_PP1_RVXF_1 120 127 PF00149 0.327
DOC_PP2B_LxvP_1 237 240 PF13499 0.416
DOC_USP7_MATH_1 138 142 PF00917 0.477
DOC_USP7_UBL2_3 115 119 PF12436 0.371
DOC_WW_Pin1_4 239 244 PF00397 0.475
DOC_WW_Pin1_4 62 67 PF00397 0.379
DOC_WW_Pin1_4 80 85 PF00397 0.448
LIG_14-3-3_CanoR_1 202 208 PF00244 0.519
LIG_14-3-3_CanoR_1 48 52 PF00244 0.520
LIG_Actin_WH2_2 56 73 PF00022 0.424
LIG_FHA_1 228 234 PF00498 0.539
LIG_FHA_2 134 140 PF00498 0.461
LIG_FHA_2 240 246 PF00498 0.431
LIG_LIR_Apic_2 133 138 PF02991 0.509
LIG_LIR_Gen_1 232 243 PF02991 0.563
LIG_LIR_Gen_1 25 36 PF02991 0.395
LIG_LIR_Nem_3 133 137 PF02991 0.448
LIG_LIR_Nem_3 2 7 PF02991 0.385
LIG_LIR_Nem_3 232 238 PF02991 0.574
LIG_LIR_Nem_3 25 31 PF02991 0.395
LIG_PTB_Apo_2 128 135 PF02174 0.432
LIG_PTB_Apo_2 34 41 PF02174 0.391
LIG_PTB_Phospho_1 34 40 PF10480 0.390
LIG_SH2_CRK 4 8 PF00017 0.380
LIG_SH2_NCK_1 135 139 PF00017 0.502
LIG_SH2_SRC 95 98 PF00017 0.433
LIG_SH2_STAP1 40 44 PF00017 0.395
LIG_SH2_STAT3 40 43 PF00017 0.393
LIG_SH2_STAT5 135 138 PF00017 0.464
LIG_SH2_STAT5 212 215 PF00017 0.466
LIG_SH2_STAT5 241 244 PF00017 0.448
LIG_SH2_STAT5 34 37 PF00017 0.394
LIG_SH3_3 237 243 PF00018 0.477
MOD_CK1_1 141 147 PF00069 0.450
MOD_CK1_1 266 272 PF00069 0.570
MOD_CK2_1 133 139 PF00069 0.456
MOD_NEK2_2 203 208 PF00069 0.462
MOD_PKA_2 47 53 PF00069 0.494
MOD_Plk_1 138 144 PF00069 0.447
MOD_Plk_2-3 133 139 PF00069 0.456
MOD_Plk_2-3 152 158 PF00069 0.565
MOD_Plk_4 263 269 PF00069 0.535
MOD_Plk_4 47 53 PF00069 0.514
MOD_ProDKin_1 239 245 PF00069 0.469
MOD_ProDKin_1 62 68 PF00069 0.382
MOD_ProDKin_1 80 86 PF00069 0.446
MOD_SUMO_rev_2 107 113 PF00179 0.483
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.407
TRG_ENDOCYTIC_2 114 117 PF00928 0.386
TRG_ENDOCYTIC_2 241 244 PF00928 0.422
TRG_ENDOCYTIC_2 4 7 PF00928 0.375
TRG_ER_diArg_1 149 151 PF00400 0.602
TRG_ER_diArg_1 184 187 PF00400 0.464
TRG_ER_diArg_1 20 22 PF00400 0.392
TRG_ER_diArg_1 220 223 PF00400 0.504
TRG_ER_diArg_1 4 6 PF00400 0.396
TRG_ER_diArg_1 72 75 PF00400 0.445
TRG_Pf-PMV_PEXEL_1 103 107 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 20 25 PF00026 0.387
TRG_Pf-PMV_PEXEL_1 231 236 PF00026 0.566
TRG_Pf-PMV_PEXEL_1 281 285 PF00026 0.447
TRG_Pf-PMV_PEXEL_1 292 296 PF00026 0.430
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.381

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCB7 Leptomonas seymouri 81% 100%
A0A0S4IJG6 Bodo saltans 58% 93%
A0A1X0NT90 Trypanosomatidae 71% 99%
A0A3Q8IAP3 Leishmania donovani 99% 100%
A0A3S7WX26 Leishmania donovani 100% 100%
A0A422NDI7 Trypanosoma rangeli 73% 100%
A4HCB5 Leishmania braziliensis 93% 98%
C9ZSF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9AVQ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q4QBR4 Leishmania major 98% 100%
V5DMI7 Trypanosoma cruzi 71% 90%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS