LeishMANIAdb
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Paraflagellar rod protein 2C

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Paraflagellar rod protein 2C
Gene product:
paraflagellar rod protein 1D - putative
Species:
Leishmania infantum
UniProt:
A0A381MH18_LEIIN
TriTrypDb:
LINF_160020200 *
Length:
599

Annotations

Annotations by Jardim et al.

Flagella, Paraflagellar rod 2C

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 8
Forrest at al. (procyclic) yes yes: 8
Silverman et al. no yes: 2
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 48
NetGPI no yes: 0, no: 48
Cellular components
Term Name Level Count
GO:0005929 cilium 4 49
GO:0031514 motile cilium 5 49
GO:0042995 cell projection 2 49
GO:0043226 organelle 2 49
GO:0043227 membrane-bounded organelle 3 49
GO:0110165 cellular anatomical entity 1 49
GO:0120025 plasma membrane bounded cell projection 3 49
GO:0005737 cytoplasm 2 3
GO:0031974 membrane-enclosed lumen 2 3
GO:0031981 nuclear lumen 5 3
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 3
GO:0043233 organelle lumen 3 3
GO:0070013 intracellular organelle lumen 4 3
GO:0097014 ciliary plasm 5 3
GO:0099568 cytoplasmic region 3 3
GO:0005930 axoneme 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A381MH18
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MH18

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 49
GO:0005515 protein binding 2 49
GO:0005516 calmodulin binding 3 49

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 166 170 PF00656 0.412
CLV_NRD_NRD_1 287 289 PF00675 0.320
CLV_NRD_NRD_1 30 32 PF00675 0.490
CLV_NRD_NRD_1 340 342 PF00675 0.323
CLV_NRD_NRD_1 363 365 PF00675 0.327
CLV_NRD_NRD_1 374 376 PF00675 0.307
CLV_NRD_NRD_1 447 449 PF00675 0.306
CLV_NRD_NRD_1 552 554 PF00675 0.309
CLV_PCSK_KEX2_1 273 275 PF00082 0.482
CLV_PCSK_KEX2_1 286 288 PF00082 0.284
CLV_PCSK_KEX2_1 316 318 PF00082 0.316
CLV_PCSK_KEX2_1 362 364 PF00082 0.320
CLV_PCSK_KEX2_1 373 375 PF00082 0.336
CLV_PCSK_KEX2_1 447 449 PF00082 0.313
CLV_PCSK_KEX2_1 462 464 PF00082 0.318
CLV_PCSK_KEX2_1 552 554 PF00082 0.323
CLV_PCSK_KEX2_1 579 581 PF00082 0.504
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.484
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.289
CLV_PCSK_PC1ET2_1 316 318 PF00082 0.323
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.322
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.319
CLV_PCSK_PC1ET2_1 579 581 PF00082 0.504
CLV_PCSK_PC7_1 370 376 PF00082 0.345
CLV_PCSK_PC7_1 575 581 PF00082 0.505
CLV_PCSK_SKI1_1 273 277 PF00082 0.459
CLV_PCSK_SKI1_1 287 291 PF00082 0.313
CLV_PCSK_SKI1_1 317 321 PF00082 0.426
CLV_PCSK_SKI1_1 389 393 PF00082 0.328
CLV_PCSK_SKI1_1 595 599 PF00082 0.688
CLV_PCSK_SKI1_1 86 90 PF00082 0.628
DOC_CYCLIN_RxL_1 386 395 PF00134 0.330
DOC_MAPK_gen_1 31 40 PF00069 0.471
DOC_MAPK_gen_1 389 396 PF00069 0.324
DOC_MAPK_gen_1 469 478 PF00069 0.320
DOC_MAPK_MEF2A_6 389 396 PF00069 0.324
DOC_MAPK_MEF2A_6 472 480 PF00069 0.330
DOC_MAPK_NFAT4_5 389 397 PF00069 0.330
DOC_PP4_FxxP_1 538 541 PF00568 0.318
DOC_USP7_MATH_1 20 24 PF00917 0.626
DOC_USP7_MATH_1 80 84 PF00917 0.550
DOC_USP7_UBL2_3 113 117 PF12436 0.467
DOC_USP7_UBL2_3 286 290 PF12436 0.295
DOC_USP7_UBL2_3 497 501 PF12436 0.300
LIG_14-3-3_CanoR_1 141 146 PF00244 0.435
LIG_14-3-3_CanoR_1 448 454 PF00244 0.310
LIG_14-3-3_CanoR_1 469 478 PF00244 0.294
LIG_14-3-3_CanoR_1 590 595 PF00244 0.549
LIG_14-3-3_CterR_2 595 599 PF00244 0.464
LIG_Actin_WH2_2 149 166 PF00022 0.420
LIG_Actin_WH2_2 389 406 PF00022 0.440
LIG_APCC_ABBA_1 436 441 PF00400 0.330
LIG_APCC_ABBAyCdc20_2 435 441 PF00400 0.330
LIG_BIR_II_1 1 5 PF00653 0.604
LIG_CtBP_PxDLS_1 103 109 PF00389 0.457
LIG_EH1_1 92 100 PF00400 0.429
LIG_eIF4E_1 235 241 PF01652 0.386
LIG_eIF4E_1 93 99 PF01652 0.429
LIG_FHA_1 138 144 PF00498 0.457
LIG_FHA_1 277 283 PF00498 0.355
LIG_FHA_1 40 46 PF00498 0.409
LIG_FHA_1 471 477 PF00498 0.277
LIG_FHA_1 579 585 PF00498 0.654
LIG_FHA_1 73 79 PF00498 0.548
LIG_FHA_2 127 133 PF00498 0.415
LIG_FHA_2 256 262 PF00498 0.427
LIG_FHA_2 318 324 PF00498 0.337
LIG_FHA_2 420 426 PF00498 0.311
LIG_LIR_Apic_2 537 541 PF02991 0.316
LIG_LIR_Gen_1 264 269 PF02991 0.563
LIG_LIR_Gen_1 355 365 PF02991 0.329
LIG_LIR_Gen_1 377 384 PF02991 0.277
LIG_LIR_Nem_3 250 255 PF02991 0.371
LIG_LIR_Nem_3 264 268 PF02991 0.565
LIG_LIR_Nem_3 337 343 PF02991 0.313
LIG_LIR_Nem_3 355 361 PF02991 0.331
LIG_LIR_Nem_3 377 381 PF02991 0.277
LIG_LIR_Nem_3 444 449 PF02991 0.307
LIG_PTB_Apo_2 44 51 PF02174 0.401
LIG_SH2_CRK 450 454 PF00017 0.336
LIG_SH2_SRC 442 445 PF00017 0.355
LIG_SH2_STAT3 318 321 PF00017 0.414
LIG_SH2_STAT3 93 96 PF00017 0.491
LIG_SH2_STAT5 235 238 PF00017 0.379
LIG_SH2_STAT5 442 445 PF00017 0.308
LIG_SH3_3 173 179 PF00018 0.505
LIG_SH3_4 113 120 PF00018 0.455
LIG_SUMO_SIM_par_1 140 146 PF11976 0.555
LIG_SUMO_SIM_par_1 390 395 PF11976 0.330
LIG_TRAF2_1 159 162 PF00917 0.514
LIG_TRAF2_1 275 278 PF00917 0.443
LIG_TRAF2_1 427 430 PF00917 0.308
LIG_TRAF2_1 46 49 PF00917 0.419
LIG_TRAF2_1 541 544 PF00917 0.320
LIG_TRAF2_1 564 567 PF00917 0.481
LIG_WRC_WIRS_1 482 487 PF05994 0.299
MOD_CK1_1 23 29 PF00069 0.517
MOD_CK1_1 57 63 PF00069 0.492
MOD_CK2_1 104 110 PF00069 0.440
MOD_CK2_1 126 132 PF00069 0.382
MOD_CK2_1 255 261 PF00069 0.389
MOD_CK2_1 317 323 PF00069 0.326
MOD_CK2_1 424 430 PF00069 0.285
MOD_CK2_1 43 49 PF00069 0.414
MOD_Cter_Amidation 284 287 PF01082 0.428
MOD_GlcNHglycan 405 408 PF01048 0.347
MOD_GlcNHglycan 417 420 PF01048 0.294
MOD_GlcNHglycan 82 85 PF01048 0.508
MOD_GSK3_1 137 144 PF00069 0.455
MOD_GSK3_1 39 46 PF00069 0.413
MOD_GSK3_1 415 422 PF00069 0.344
MOD_N-GLC_1 137 142 PF02516 0.462
MOD_N-GLC_1 188 193 PF02516 0.398
MOD_N-GLC_1 261 266 PF02516 0.449
MOD_NEK2_1 104 109 PF00069 0.440
MOD_NEK2_1 126 131 PF00069 0.420
MOD_NEK2_1 163 168 PF00069 0.418
MOD_NEK2_1 188 193 PF00069 0.393
MOD_NEK2_1 276 281 PF00069 0.336
MOD_NEK2_1 392 397 PF00069 0.308
MOD_NEK2_1 403 408 PF00069 0.303
MOD_NEK2_1 449 454 PF00069 0.305
MOD_NEK2_1 578 583 PF00069 0.518
MOD_PIKK_1 163 169 PF00454 0.431
MOD_PIKK_1 268 274 PF00454 0.547
MOD_PIKK_1 317 323 PF00454 0.339
MOD_PIKK_1 583 589 PF00454 0.535
MOD_PIKK_1 59 65 PF00454 0.512
MOD_PKA_1 490 496 PF00069 0.336
MOD_PKA_2 163 169 PF00069 0.431
MOD_PKA_2 403 409 PF00069 0.344
MOD_PKA_2 471 477 PF00069 0.305
MOD_PKA_2 551 557 PF00069 0.313
MOD_Plk_1 104 110 PF00069 0.490
MOD_Plk_1 188 194 PF00069 0.420
MOD_Plk_1 23 29 PF00069 0.539
MOD_Plk_1 261 267 PF00069 0.497
MOD_Plk_1 392 398 PF00069 0.340
MOD_Plk_2-3 261 267 PF00069 0.339
MOD_Plk_2-3 296 302 PF00069 0.402
MOD_Plk_4 188 194 PF00069 0.437
MOD_Plk_4 392 398 PF00069 0.326
MOD_SUMO_for_1 154 157 PF00179 0.452
MOD_SUMO_for_1 495 498 PF00179 0.333
MOD_SUMO_for_1 564 567 PF00179 0.479
MOD_SUMO_rev_2 110 118 PF00179 0.452
MOD_SUMO_rev_2 259 265 PF00179 0.402
MOD_SUMO_rev_2 567 572 PF00179 0.446
MOD_SUMO_rev_2 574 581 PF00179 0.425
TRG_DiLeu_BaEn_2 376 382 PF01217 0.330
TRG_DiLeu_BaEn_3 507 513 PF01217 0.331
TRG_DiLeu_BaEn_4 429 435 PF01217 0.373
TRG_DiLeu_BaEn_4 508 514 PF01217 0.316
TRG_ENDOCYTIC_2 378 381 PF00928 0.266
TRG_ENDOCYTIC_2 450 453 PF00928 0.308
TRG_ER_diArg_1 287 289 PF00400 0.317
TRG_ER_diArg_1 363 365 PF00400 0.317
TRG_ER_diArg_1 373 375 PF00400 0.321
TRG_ER_diArg_1 446 448 PF00400 0.329
TRG_NES_CRM1_1 242 257 PF08389 0.368
TRG_NES_CRM1_1 96 110 PF08389 0.513
TRG_NLS_Bipartite_1 273 290 PF00514 0.336
TRG_NLS_MonoExtC_3 285 290 PF00514 0.330
TRG_NLS_MonoExtN_4 283 290 PF00514 0.330
TRG_Pf-PMV_PEXEL_1 128 132 PF00026 0.455
TRG_Pf-PMV_PEXEL_1 253 257 PF00026 0.416
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.322
TRG_Pf-PMV_PEXEL_1 341 345 PF00026 0.324
TRG_Pf-PMV_PEXEL_1 363 367 PF00026 0.309
TRG_Pf-PMV_PEXEL_1 389 393 PF00026 0.322
TRG_Pf-PMV_PEXEL_1 462 466 PF00026 0.320
TRG_Pf-PMV_PEXEL_1 595 599 PF00026 0.491

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2I5 Leptomonas seymouri 66% 100%
A0A0N0P5J5 Leptomonas seymouri 26% 75%
A0A0N1IFZ5 Leptomonas seymouri 95% 100%
A0A0S4IW44 Bodo saltans 25% 90%
A0A0S4IZY8 Bodo saltans 84% 100%
A0A0S4J013 Bodo saltans 25% 91%
A0A0S4J193 Bodo saltans 28% 97%
A0A0S4J561 Bodo saltans 30% 85%
A0A0S4JS20 Bodo saltans 69% 100%
A0A1X0NR57 Trypanosomatidae 26% 76%
A0A1X0NYU4 Trypanosomatidae 85% 100%
A0A1X0P0B7 Trypanosomatidae 69% 100%
A0A381MN58 Leishmania infantum 67% 100%
A0A3Q8IAP5 Leishmania donovani 100% 100%
A0A3Q8IEH2 Leishmania donovani 67% 100%
A0A3R7KDB9 Trypanosoma rangeli 84% 100%
A0A3S5IRI8 Trypanosoma rangeli 69% 100%
A0A3S7WQV4 Leishmania donovani 22% 99%
A0A3S7X0V5 Leishmania donovani 24% 77%
A0A3S7X2K1 Leishmania donovani 67% 100%
A0A422NJR9 Trypanosoma rangeli 25% 81%
A4H5W0 Leishmania braziliensis 24% 100%
A4H8S1 Leishmania braziliensis 94% 100%
A4HFV9 Leishmania braziliensis 25% 100%
A4HIY0 Leishmania braziliensis 66% 100%
A4HU55 Leishmania infantum 21% 99%
A4HX40 Leishmania infantum 100% 100%
A4I2Z1 Leishmania infantum 24% 77%
C9ZJD8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 79%
C9ZLC1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
C9ZLC2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
C9ZU76 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 87%
C9ZVV0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
E9ADG3 Leishmania major 25% 100%
E9AE36 Leishmania major 67% 100%
E9AE37 Leishmania major 67% 100%
E9AHJ2 Leishmania infantum 67% 100%
E9ALP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
E9ALP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
E9AMY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AQV6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
E9AZ87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
P22225 Trypanosoma brucei brucei 83% 100%
Q26789 Trypanosoma brucei brucei 67% 100%
Q4QEM2 Leishmania major 99% 100%
Q4QHP3 Leishmania major 22% 99%
V5ARJ3 Trypanosoma cruzi 28% 86%
V5BDW8 Trypanosoma cruzi 69% 100%
V5BIN9 Trypanosoma cruzi 27% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS