Paraflagellar rod protein 2C

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 1D - putative

Species:

Leishmania infantum

UniProt:

A0A381MH18_LEIIN

TriTrypDb:

LINF_160020200

Length:

599

Annotations

Annotations by Jardim et al.

Flagella, Paraflagellar rod 2C

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 8
Forrest at al. (procyclic)	yes	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 48
NetGPI	no	yes: 0, no: 48

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005929	cilium	4	49
GO:0005930	axoneme	2	1
GO:0031514	motile cilium	5	49
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0042995	cell projection	2	49
GO:0043226	organelle	2	49
GO:0043227	membrane-bounded organelle	3	49

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A381MH18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MH18

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	49
GO:0005515	protein binding	2	49
GO:0005516	calmodulin binding	3	49

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.412
CLV_NRD_NRD_1	287	289	PF00675	0.320
CLV_NRD_NRD_1	30	32	PF00675	0.490
CLV_NRD_NRD_1	340	342	PF00675	0.323
CLV_NRD_NRD_1	363	365	PF00675	0.327
CLV_NRD_NRD_1	374	376	PF00675	0.307
CLV_NRD_NRD_1	447	449	PF00675	0.306
CLV_NRD_NRD_1	552	554	PF00675	0.309
CLV_PCSK_KEX2_1	273	275	PF00082	0.482
CLV_PCSK_KEX2_1	286	288	PF00082	0.284

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	66%	100%
A0A0N0P5J5	Leptomonas seymouri	26%	75%
A0A0N1IFZ5	Leptomonas seymouri	95%	100%
A0A0S4IW44	Bodo saltans	25%	90%
A0A0S4IZY8	Bodo saltans	84%	100%
A0A0S4J013	Bodo saltans	25%	91%
A0A0S4J193	Bodo saltans	28%	97%
A0A0S4J561	Bodo saltans	30%	85%
A0A0S4JS20	Bodo saltans	69%	100%
A0A1X0NR57	Trypanosomatidae	26%	76%

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