ZP domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A0A381MFS8_LEIIN

TriTrypDb:

LINF_140009000

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 264, 281

Expansion

Sequence features

A0A381MFS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MFS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.389
CLV_C14_Caspase3-7	96	100	PF00656	0.378
CLV_NRD_NRD_1	189	191	PF00675	0.528
CLV_NRD_NRD_1	206	208	PF00675	0.353
CLV_NRD_NRD_1	285	287	PF00675	0.581
CLV_PCSK_SKI1_1	116	120	PF00082	0.406
CLV_PCSK_SKI1_1	166	170	PF00082	0.501
CLV_PCSK_SKI1_1	20	24	PF00082	0.355
DEG_APCC_DBOX_1	19	27	PF00400	0.318
DOC_MAPK_gen_1	48	57	PF00069	0.329
DOC_MAPK_MEF2A_6	58	67	PF00069	0.343
DOC_PP1_RVXF_1	258	264	PF00149	0.462
DOC_PP1_RVXF_1	46	52	PF00149	0.345
DOC_USP7_MATH_1	162	166	PF00917	0.405
LIG_14-3-3_CanoR_1	190	195	PF00244	0.509
LIG_14-3-3_CanoR_1	260	270	PF00244	0.398
LIG_14-3-3_CanoR_1	286	296	PF00244	0.511
LIG_14-3-3_CanoR_1	90	98	PF00244	0.370
LIG_BRCT_BRCA1_1	164	168	PF00533	0.312
LIG_FHA_1	122	128	PF00498	0.370
LIG_FHA_1	133	139	PF00498	0.385
LIG_FHA_1	147	153	PF00498	0.248
LIG_FHA_1	155	161	PF00498	0.336
LIG_FHA_1	171	177	PF00498	0.323
LIG_FHA_1	197	203	PF00498	0.513
LIG_FHA_1	237	243	PF00498	0.419
LIG_FHA_1	252	258	PF00498	0.428
LIG_FHA_1	293	299	PF00498	0.510
LIG_FHA_1	31	37	PF00498	0.368
LIG_FHA_2	273	279	PF00498	0.479
LIG_FHA_2	304	310	PF00498	0.447
LIG_LIR_Apic_2	147	153	PF02991	0.332
LIG_LIR_Gen_1	193	202	PF02991	0.392
LIG_LIR_Gen_1	44	53	PF02991	0.410
LIG_LIR_LC3C_4	133	138	PF02991	0.328
LIG_LIR_Nem_3	193	197	PF02991	0.353
LIG_LIR_Nem_3	199	203	PF02991	0.306
LIG_LIR_Nem_3	27	32	PF02991	0.383
LIG_LIR_Nem_3	44	49	PF02991	0.352
LIG_SH2_CRK	69	73	PF00017	0.385
LIG_SH2_SRC	194	197	PF00017	0.295
LIG_SH2_STAP1	194	198	PF00017	0.293
LIG_SH2_STAP1	77	81	PF00017	0.305
LIG_SH2_STAT5	200	203	PF00017	0.390
LIG_SH2_STAT5	226	229	PF00017	0.329
LIG_SH2_STAT5	32	35	PF00017	0.477
LIG_SH2_STAT5	66	69	PF00017	0.303
LIG_SH2_STAT5	80	83	PF00017	0.296
LIG_SH3_1	69	75	PF00018	0.399
LIG_SH3_3	69	75	PF00018	0.378
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.361
LIG_UBA3_1	175	184	PF00899	0.339
MOD_CK1_1	144	150	PF00069	0.337
MOD_CK1_1	164	170	PF00069	0.239
MOD_CK1_1	236	242	PF00069	0.569
MOD_CK1_1	30	36	PF00069	0.439
MOD_CK2_1	227	233	PF00069	0.343
MOD_CK2_1	242	248	PF00069	0.321
MOD_CK2_1	81	87	PF00069	0.413
MOD_Cter_Amidation	188	191	PF01082	0.405
MOD_GlcNHglycan	16	20	PF01048	0.483
MOD_GlcNHglycan	220	223	PF01048	0.510
MOD_GlcNHglycan	233	238	PF01048	0.571
MOD_GlcNHglycan	265	268	PF01048	0.499
MOD_GlcNHglycan	278	283	PF01048	0.626
MOD_GSK3_1	144	151	PF00069	0.369
MOD_GSK3_1	274	281	PF00069	0.775
MOD_GSK3_1	288	295	PF00069	0.636
MOD_GSK3_1	30	37	PF00069	0.351
MOD_GSK3_1	75	82	PF00069	0.372
MOD_GSK3_1	8	15	PF00069	0.493
MOD_GSK3_1	86	93	PF00069	0.390
MOD_N-GLC_1	144	149	PF02516	0.394
MOD_N-GLC_1	261	266	PF02516	0.330
MOD_N-GLC_1	41	46	PF02516	0.383
MOD_N-GLC_2	108	110	PF02516	0.339
MOD_N-GLC_2	159	161	PF02516	0.309
MOD_N-GLC_2	292	294	PF02516	0.497
MOD_NEK2_1	141	146	PF00069	0.432
MOD_NEK2_1	218	223	PF00069	0.539
MOD_NEK2_1	227	232	PF00069	0.541
MOD_NEK2_1	263	268	PF00069	0.641
MOD_NEK2_1	272	277	PF00069	0.579
MOD_NEK2_1	53	58	PF00069	0.327
MOD_NEK2_1	81	86	PF00069	0.381
MOD_PIKK_1	154	160	PF00454	0.356
MOD_PIKK_1	27	33	PF00454	0.577
MOD_PKA_1	190	196	PF00069	0.439
MOD_PKA_1	286	292	PF00069	0.570
MOD_Plk_1	121	127	PF00069	0.392
MOD_Plk_1	132	138	PF00069	0.318
MOD_Plk_1	144	150	PF00069	0.301
MOD_Plk_1	242	248	PF00069	0.346
MOD_Plk_1	41	47	PF00069	0.387
MOD_Plk_2-3	303	309	PF00069	0.628
MOD_Plk_4	121	127	PF00069	0.366
MOD_Plk_4	132	138	PF00069	0.351
MOD_Plk_4	170	176	PF00069	0.388
MOD_Plk_4	196	202	PF00069	0.434
MOD_Plk_4	303	309	PF00069	0.534
MOD_Plk_4	75	81	PF00069	0.315
MOD_SUMO_for_1	153	156	PF00179	0.328
MOD_SUMO_rev_2	111	118	PF00179	0.423
MOD_SUMO_rev_2	279	289	PF00179	0.542
MOD_SUMO_rev_2	299	304	PF00179	0.476
TRG_DiLeu_BaEn_1	121	126	PF01217	0.310
TRG_ENDOCYTIC_2	194	197	PF00928	0.485
TRG_ENDOCYTIC_2	200	203	PF00928	0.417
TRG_ENDOCYTIC_2	226	229	PF00928	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0V1	Leptomonas seymouri	52%	100%
A0A0S4KDQ4	Bodo saltans	43%	100%
A0A1X0NQ77	Trypanosomatidae	44%	99%
A0A3Q8I9T1	Leishmania donovani	85%	100%
A0A3R7N2S2	Trypanosoma rangeli	42%	97%
A0A3S7WSX7	Leishmania donovani	100%	100%
A4H7J8	Leishmania braziliensis	51%	100%
C9ZT43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9AGK8	Leishmania infantum	89%	100%
E9APN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9APN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E9APN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QFU5	Leishmania major	76%	100%
Q4QFU6	Leishmania major	81%	100%
V5BD72	Trypanosoma cruzi	43%	97%