LeishMANIAdb
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Putative amino acid transporter

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid transporter
Gene product:
amino acid permease 24 - putative
Species:
Leishmania infantum
UniProt:
A0A381MBS1_LEIIN
TriTrypDb:
LINF_100013850 *
Length:
488

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Annotations by Jardim et al.

Transporters, Proline amino acid transporter AAT20.1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18
GO:0005774 vacuolar membrane 5 2
GO:0031090 organelle membrane 3 2
GO:0098588 bounding membrane of organelle 4 2

Phosphorylation

Promastigote: 45

Expansion

Sequence features

A0A381MBS1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381MBS1

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 2
GO:0006810 transport 3 2
GO:0006865 amino acid transport 5 2
GO:0009987 cellular process 1 2
GO:0015849 organic acid transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:1903825 organic acid transmembrane transport 3 2
GO:1905039 carboxylic acid transmembrane transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005342 organic acid transmembrane transporter activity 3 2
GO:0015171 amino acid transmembrane transporter activity 5 2
GO:0015179 L-amino acid transmembrane transporter activity 6 2
GO:0022857 transmembrane transporter activity 2 2
GO:0046943 carboxylic acid transmembrane transporter activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 437 441 PF00656 0.621
CLV_C14_Caspase3-7 7 11 PF00656 0.673
CLV_PCSK_KEX2_1 296 298 PF00082 0.343
CLV_PCSK_KEX2_1 462 464 PF00082 0.376
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.343
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.323
CLV_PCSK_SKI1_1 301 305 PF00082 0.285
CLV_PCSK_SKI1_1 347 351 PF00082 0.291
CLV_PCSK_SKI1_1 450 454 PF00082 0.329
CLV_PCSK_SKI1_1 88 92 PF00082 0.232
DEG_APCC_KENBOX_2 80 84 PF00400 0.579
DOC_MAPK_FxFP_2 356 359 PF00069 0.312
DOC_MAPK_gen_1 196 205 PF00069 0.263
DOC_MAPK_gen_1 374 383 PF00069 0.450
DOC_MAPK_gen_1 462 472 PF00069 0.484
DOC_MAPK_HePTP_8 373 385 PF00069 0.494
DOC_MAPK_MEF2A_6 133 142 PF00069 0.345
DOC_MAPK_MEF2A_6 196 205 PF00069 0.303
DOC_MAPK_MEF2A_6 347 356 PF00069 0.309
DOC_MAPK_MEF2A_6 376 385 PF00069 0.442
DOC_MAPK_MEF2A_6 386 393 PF00069 0.237
DOC_MAPK_MEF2A_6 463 472 PF00069 0.464
DOC_MAPK_NFAT4_5 386 394 PF00069 0.312
DOC_PP1_RVXF_1 345 351 PF00149 0.319
DOC_PP4_FxxP_1 103 106 PF00568 0.271
DOC_PP4_FxxP_1 356 359 PF00568 0.339
DOC_USP7_MATH_1 224 228 PF00917 0.312
DOC_USP7_MATH_1 230 234 PF00917 0.335
DOC_USP7_MATH_1 338 342 PF00917 0.268
DOC_USP7_MATH_1 414 418 PF00917 0.377
LIG_14-3-3_CanoR_1 3 13 PF00244 0.758
LIG_14-3-3_CanoR_1 443 447 PF00244 0.517
LIG_BIR_II_1 1 5 PF00653 0.727
LIG_BRCT_BRCA1_1 203 207 PF00533 0.418
LIG_EH1_1 113 121 PF00400 0.300
LIG_EH1_1 348 356 PF00400 0.168
LIG_FHA_1 130 136 PF00498 0.382
LIG_FHA_1 229 235 PF00498 0.331
LIG_FHA_1 302 308 PF00498 0.465
LIG_FHA_1 318 324 PF00498 0.230
LIG_FHA_1 328 334 PF00498 0.233
LIG_FHA_1 355 361 PF00498 0.345
LIG_FHA_1 400 406 PF00498 0.310
LIG_FHA_1 479 485 PF00498 0.322
LIG_FHA_2 15 21 PF00498 0.668
LIG_FHA_2 186 192 PF00498 0.322
LIG_FHA_2 25 31 PF00498 0.698
LIG_FHA_2 5 11 PF00498 0.742
LIG_GBD_Chelix_1 115 123 PF00786 0.365
LIG_GBD_Chelix_1 311 319 PF00786 0.420
LIG_LIR_Apic_2 100 106 PF02991 0.290
LIG_LIR_Gen_1 148 157 PF02991 0.475
LIG_LIR_Gen_1 198 208 PF02991 0.285
LIG_LIR_Gen_1 233 244 PF02991 0.359
LIG_LIR_Gen_1 30 38 PF02991 0.671
LIG_LIR_Gen_1 60 68 PF02991 0.726
LIG_LIR_Gen_1 89 98 PF02991 0.330
LIG_LIR_Nem_3 148 153 PF02991 0.435
LIG_LIR_Nem_3 198 203 PF02991 0.293
LIG_LIR_Nem_3 233 239 PF02991 0.348
LIG_LIR_Nem_3 30 35 PF02991 0.706
LIG_LIR_Nem_3 320 325 PF02991 0.358
LIG_LIR_Nem_3 379 383 PF02991 0.467
LIG_LIR_Nem_3 460 464 PF02991 0.493
LIG_LIR_Nem_3 89 94 PF02991 0.330
LIG_PALB2_WD40_1 265 273 PF16756 0.294
LIG_PDZ_Class_3 483 488 PF00595 0.356
LIG_Pex14_1 313 317 PF04695 0.338
LIG_Pex14_1 449 453 PF04695 0.569
LIG_Pex14_2 207 211 PF04695 0.342
LIG_PTB_Apo_2 350 357 PF02174 0.352
LIG_SH2_CRK 150 154 PF00017 0.485
LIG_SH2_CRK 181 185 PF00017 0.360
LIG_SH2_CRK 236 240 PF00017 0.397
LIG_SH2_NCK_1 482 486 PF00017 0.372
LIG_SH2_PTP2 467 470 PF00017 0.432
LIG_SH2_STAP1 181 185 PF00017 0.342
LIG_SH2_STAT3 358 361 PF00017 0.290
LIG_SH2_STAT5 114 117 PF00017 0.324
LIG_SH2_STAT5 156 159 PF00017 0.466
LIG_SH2_STAT5 181 184 PF00017 0.293
LIG_SH2_STAT5 200 203 PF00017 0.312
LIG_SH2_STAT5 314 317 PF00017 0.294
LIG_SH2_STAT5 322 325 PF00017 0.306
LIG_SH2_STAT5 467 470 PF00017 0.271
LIG_SH2_STAT5 61 64 PF00017 0.730
LIG_SH3_3 433 439 PF00018 0.514
LIG_SH3_3 451 457 PF00018 0.611
LIG_SUMO_SIM_anti_2 217 224 PF11976 0.462
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.338
LIG_SUMO_SIM_par_1 221 227 PF11976 0.472
LIG_SUMO_SIM_par_1 303 308 PF11976 0.383
LIG_TYR_ITIM 179 184 PF00017 0.319
LIG_TYR_ITIM 234 239 PF00017 0.397
LIG_TYR_ITSM 146 153 PF00017 0.515
LIG_UBA3_1 427 433 PF00899 0.222
LIG_Vh1_VBS_1 337 355 PF01044 0.149
LIG_WRC_WIRS_1 105 110 PF05994 0.319
MOD_CK1_1 145 151 PF00069 0.457
MOD_CK1_1 328 334 PF00069 0.340
MOD_CK1_1 341 347 PF00069 0.195
MOD_CK1_1 6 12 PF00069 0.714
MOD_CK2_1 14 20 PF00069 0.651
MOD_CK2_1 185 191 PF00069 0.323
MOD_CK2_1 24 30 PF00069 0.695
MOD_CK2_1 31 37 PF00069 0.674
MOD_CK2_1 480 486 PF00069 0.288
MOD_CK2_1 6 12 PF00069 0.711
MOD_GlcNHglycan 363 366 PF01048 0.333
MOD_GlcNHglycan 402 405 PF01048 0.495
MOD_GlcNHglycan 88 91 PF01048 0.278
MOD_GSK3_1 142 149 PF00069 0.536
MOD_GSK3_1 214 221 PF00069 0.331
MOD_GSK3_1 224 231 PF00069 0.294
MOD_GSK3_1 301 308 PF00069 0.489
MOD_GSK3_1 325 332 PF00069 0.316
MOD_GSK3_1 337 344 PF00069 0.281
MOD_GSK3_1 400 407 PF00069 0.365
MOD_GSK3_1 480 487 PF00069 0.309
MOD_N-GLC_1 142 147 PF02516 0.371
MOD_N-GLC_1 218 223 PF02516 0.253
MOD_N-GLC_2 85 87 PF02516 0.149
MOD_NEK2_1 179 184 PF00069 0.324
MOD_NEK2_1 185 190 PF00069 0.300
MOD_NEK2_1 195 200 PF00069 0.231
MOD_NEK2_1 201 206 PF00069 0.330
MOD_NEK2_1 242 247 PF00069 0.355
MOD_NEK2_1 305 310 PF00069 0.383
MOD_NEK2_1 317 322 PF00069 0.256
MOD_NEK2_1 329 334 PF00069 0.198
MOD_NEK2_1 337 342 PF00069 0.249
MOD_NEK2_1 354 359 PF00069 0.348
MOD_NEK2_2 230 235 PF00069 0.427
MOD_NEK2_2 342 347 PF00069 0.298
MOD_NEK2_2 457 462 PF00069 0.608
MOD_OFUCOSY 210 215 PF10250 0.309
MOD_PIKK_1 14 20 PF00454 0.646
MOD_PIKK_1 148 154 PF00454 0.494
MOD_PIKK_1 179 185 PF00454 0.316
MOD_PIKK_1 247 253 PF00454 0.333
MOD_PIKK_1 291 297 PF00454 0.502
MOD_PKA_2 24 30 PF00069 0.665
MOD_PKA_2 442 448 PF00069 0.511
MOD_Plk_1 129 135 PF00069 0.312
MOD_Plk_1 145 151 PF00069 0.459
MOD_Plk_1 218 224 PF00069 0.453
MOD_Plk_1 369 375 PF00069 0.509
MOD_Plk_1 68 74 PF00069 0.613
MOD_Plk_4 104 110 PF00069 0.287
MOD_Plk_4 114 120 PF00069 0.287
MOD_Plk_4 185 191 PF00069 0.213
MOD_Plk_4 201 207 PF00069 0.304
MOD_Plk_4 218 224 PF00069 0.380
MOD_Plk_4 230 236 PF00069 0.224
MOD_Plk_4 24 30 PF00069 0.685
MOD_Plk_4 242 248 PF00069 0.244
MOD_Plk_4 301 307 PF00069 0.470
MOD_Plk_4 329 335 PF00069 0.232
MOD_Plk_4 404 410 PF00069 0.276
MOD_Plk_4 423 429 PF00069 0.375
MOD_Plk_4 68 74 PF00069 0.651
MOD_SUMO_rev_2 50 58 PF00179 0.770
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.341
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.405
TRG_ENDOCYTIC_2 150 153 PF00928 0.447
TRG_ENDOCYTIC_2 181 184 PF00928 0.330
TRG_ENDOCYTIC_2 200 203 PF00928 0.278
TRG_ENDOCYTIC_2 236 239 PF00928 0.374
TRG_ENDOCYTIC_2 314 317 PF00928 0.297
TRG_ENDOCYTIC_2 467 470 PF00928 0.296
TRG_ENDOCYTIC_2 61 64 PF00928 0.730
TRG_NLS_Bipartite_1 450 466 PF00514 0.552
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.420

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6H0 Leptomonas seymouri 70% 100%
A0A0N0P8T9 Leptomonas seymouri 21% 98%
A0A0N1PCP5 Leptomonas seymouri 69% 100%
A0A1X0NHS6 Trypanosomatidae 46% 100%
A0A1X0NRL3 Trypanosomatidae 24% 100%
A0A1X0NYI3 Trypanosomatidae 22% 98%
A0A1X0NZK6 Trypanosomatidae 48% 100%
A0A1X0P7Z8 Trypanosomatidae 31% 78%
A0A3Q8IB21 Leishmania donovani 99% 100%
A0A3Q8IFZ0 Leishmania donovani 23% 95%
A0A3S5H6G5 Leishmania donovani 99% 100%
A0A3S5H6T4 Leishmania donovani 24% 96%
A0A3S7WQ39 Leishmania donovani 21% 100%
A0A422MW74 Trypanosoma rangeli 21% 95%
A0A422MZQ8 Trypanosoma rangeli 35% 82%
A0A422NBM3 Trypanosoma rangeli 20% 100%
A4H565 Leishmania braziliensis 21% 100%
A4H662 Leishmania braziliensis 79% 100%
A4HKQ7 Leishmania braziliensis 23% 100%
A4HNZ6 Leishmania braziliensis 30% 100%
A4HTE2 Leishmania infantum 22% 99%
A4HUI4 Leishmania infantum 99% 100%
A4I6K0 Leishmania infantum 23% 95%
C9ZW15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A2X2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 85%
E9AN82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AYW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
F4ILY9 Arabidopsis thaliana 24% 100%
P36062 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 71%
Q10074 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 74%
Q495M3 Homo sapiens 21% 100%
Q495N2 Homo sapiens 23% 100%
Q4KL91 Xenopus laevis 21% 93%
Q4Q6M8 Leishmania major 24% 95%
Q4QHE2 Leishmania major 94% 100%
Q4QHE4 Leishmania major 93% 100%
Q4QIH0 Leishmania major 24% 100%
Q4V8B1 Rattus norvegicus 24% 100%
Q6YBV0 Homo sapiens 22% 97%
Q7Z2H8 Homo sapiens 22% 100%
Q811P0 Mus musculus 23% 100%
Q8CH36 Mus musculus 22% 98%
Q8K415 Rattus norvegicus 22% 100%
Q8K4D3 Mus musculus 23% 100%
Q924A5 Rattus norvegicus 22% 100%
Q9SF09 Arabidopsis thaliana 22% 100%
Q9SS86 Arabidopsis thaliana 21% 100%
Q9SVG0 Arabidopsis thaliana 24% 100%
Q9VT04 Drosophila melanogaster 21% 100%
Q9W056 Drosophila melanogaster 25% 100%
V5BHF0 Trypanosoma cruzi 42% 100%
V5BJY7 Trypanosoma cruzi 34% 82%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS