TNFR-Cys domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A0A381M9M8_LEIIN

TriTrypDb:

LINF_040006700

Length:

528

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Annotations by Jardim et al.

Proteases, peptidase M8

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 7
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A381M9M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A381M9M8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008233	peptidase activity	3	3
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.596
CLV_C14_Caspase3-7	37	41	PF00656	0.340
CLV_PCSK_SKI1_1	34	38	PF00082	0.586
DOC_MAPK_FxFP_2	282	285	PF00069	0.586
DOC_PP4_FxxP_1	282	285	PF00568	0.615
DOC_USP7_MATH_1	110	114	PF00917	0.643
DOC_USP7_MATH_1	126	130	PF00917	0.495
DOC_USP7_MATH_1	137	141	PF00917	0.581
DOC_USP7_MATH_1	154	158	PF00917	0.598
DOC_USP7_MATH_1	224	228	PF00917	0.612
DOC_USP7_MATH_1	275	279	PF00917	0.621
DOC_USP7_MATH_1	319	323	PF00917	0.627
DOC_USP7_MATH_1	385	389	PF00917	0.670
DOC_USP7_MATH_1	473	477	PF00917	0.588
DOC_USP7_MATH_1	479	483	PF00917	0.576
DOC_USP7_MATH_1	79	83	PF00917	0.479
DOC_WW_Pin1_4	80	85	PF00397	0.454
LIG_14-3-3_CanoR_1	116	126	PF00244	0.636
LIG_14-3-3_CanoR_1	220	228	PF00244	0.544
LIG_14-3-3_CanoR_1	439	447	PF00244	0.661
LIG_14-3-3_CanoR_1	490	496	PF00244	0.628
LIG_14-3-3_CanoR_1	88	92	PF00244	0.468
LIG_BRCT_BRCA1_1	236	240	PF00533	0.631
LIG_FHA_1	119	125	PF00498	0.570
LIG_FHA_1	141	147	PF00498	0.644
LIG_FHA_1	158	164	PF00498	0.496
LIG_FHA_1	176	182	PF00498	0.590
LIG_FHA_1	31	37	PF00498	0.450
LIG_FHA_1	406	412	PF00498	0.567
LIG_FHA_1	45	51	PF00498	0.301
LIG_FHA_1	456	462	PF00498	0.573
LIG_FHA_1	510	516	PF00498	0.450
LIG_FHA_1	59	65	PF00498	0.323
LIG_FHA_2	260	266	PF00498	0.563
LIG_FHA_2	284	290	PF00498	0.633
LIG_FHA_2	35	41	PF00498	0.419
LIG_FHA_2	357	363	PF00498	0.628
LIG_FHA_2	439	445	PF00498	0.547
LIG_LIR_Gen_1	44	52	PF02991	0.373
LIG_LIR_Gen_1	471	480	PF02991	0.538
LIG_LIR_Nem_3	132	136	PF02991	0.638
LIG_LIR_Nem_3	304	310	PF02991	0.614
LIG_LIR_Nem_3	40	46	PF02991	0.453
LIG_LIR_Nem_3	471	477	PF02991	0.533
LIG_PDZ_Class_2	523	528	PF00595	0.651
LIG_SH2_CRK	474	478	PF00017	0.529
LIG_SH2_SRC	269	272	PF00017	0.487
LIG_SH2_STAP1	46	50	PF00017	0.418
LIG_SH2_STAT5	269	272	PF00017	0.610
LIG_SH2_STAT5	46	49	PF00017	0.420
LIG_SH2_STAT5	474	477	PF00017	0.594
LIG_SH2_STAT5	493	496	PF00017	0.547
LIG_SH3_3	148	154	PF00018	0.665
LIG_SH3_3	407	413	PF00018	0.569
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.616
LIG_SUMO_SIM_par_1	101	106	PF11976	0.285
LIG_SUMO_SIM_par_1	142	147	PF11976	0.622
LIG_SUMO_SIM_par_1	162	167	PF11976	0.449
LIG_SUMO_SIM_par_1	193	199	PF11976	0.529
LIG_SUMO_SIM_par_1	230	235	PF11976	0.626
LIG_SUMO_SIM_par_1	47	56	PF11976	0.434
LIG_TRAF2_2	413	418	PF00917	0.584
MOD_CK1_1	101	107	PF00069	0.356
MOD_CK1_1	140	146	PF00069	0.584
MOD_CK1_1	157	163	PF00069	0.534
MOD_CK1_1	167	173	PF00069	0.508
MOD_CK1_1	193	199	PF00069	0.517
MOD_CK1_1	257	263	PF00069	0.652
MOD_CK1_1	264	270	PF00069	0.611
MOD_CK1_1	283	289	PF00069	0.568
MOD_CK1_1	300	306	PF00069	0.558
MOD_CK1_1	356	362	PF00069	0.612
MOD_CK1_1	367	373	PF00069	0.600
MOD_CK1_1	39	45	PF00069	0.486
MOD_CK1_1	484	490	PF00069	0.668
MOD_CK1_1	53	59	PF00069	0.341
MOD_CK1_1	67	73	PF00069	0.376
MOD_CK1_1	82	88	PF00069	0.391
MOD_CK2_1	271	277	PF00069	0.609
MOD_CK2_1	283	289	PF00069	0.621
MOD_CK2_1	385	391	PF00069	0.611
MOD_GlcNHglycan	105	108	PF01048	0.453
MOD_GlcNHglycan	132	136	PF01048	0.435
MOD_GlcNHglycan	166	169	PF01048	0.438
MOD_GlcNHglycan	222	225	PF01048	0.366
MOD_GlcNHglycan	256	259	PF01048	0.453
MOD_GlcNHglycan	265	269	PF01048	0.344
MOD_GlcNHglycan	273	276	PF01048	0.266
MOD_GlcNHglycan	277	280	PF01048	0.344
MOD_GlcNHglycan	299	302	PF01048	0.411
MOD_GlcNHglycan	367	370	PF01048	0.459
MOD_GlcNHglycan	387	390	PF01048	0.377
MOD_GlcNHglycan	481	484	PF01048	0.460
MOD_GlcNHglycan	55	58	PF01048	0.623
MOD_GlcNHglycan	69	72	PF01048	0.583
MOD_GlcNHglycan	85	88	PF01048	0.552
MOD_GSK3_1	199	206	PF00069	0.632
MOD_GSK3_1	220	227	PF00069	0.546
MOD_GSK3_1	253	260	PF00069	0.641
MOD_GSK3_1	26	33	PF00069	0.553
MOD_GSK3_1	271	278	PF00069	0.646
MOD_GSK3_1	297	304	PF00069	0.621
MOD_GSK3_1	319	326	PF00069	0.650
MOD_GSK3_1	345	352	PF00069	0.592
MOD_GSK3_1	356	363	PF00069	0.538
MOD_GSK3_1	383	390	PF00069	0.669
MOD_GSK3_1	391	398	PF00069	0.602
MOD_GSK3_1	434	441	PF00069	0.659
MOD_GSK3_1	455	462	PF00069	0.638
MOD_GSK3_1	481	488	PF00069	0.610
MOD_GSK3_1	79	86	PF00069	0.526
MOD_GSK3_1	94	101	PF00069	0.278
MOD_N-GLC_1	140	145	PF02516	0.430
MOD_N-GLC_1	184	189	PF02516	0.342
MOD_N-GLC_2	438	440	PF02516	0.381
MOD_NEK2_1	131	136	PF00069	0.620
MOD_NEK2_1	184	189	PF00069	0.571
MOD_NEK2_1	254	259	PF00069	0.618
MOD_NEK2_1	297	302	PF00069	0.615
MOD_NEK2_1	310	315	PF00069	0.532
MOD_NEK2_1	327	332	PF00069	0.522
MOD_NEK2_1	406	411	PF00069	0.577
MOD_NEK2_1	50	55	PF00069	0.348
MOD_NEK2_1	64	69	PF00069	0.328
MOD_NEK2_1	93	98	PF00069	0.412
MOD_NEK2_2	126	131	PF00069	0.555
MOD_PIKK_1	196	202	PF00454	0.603
MOD_PIKK_1	360	366	PF00454	0.585
MOD_PIKK_1	64	70	PF00454	0.438
MOD_PKA_2	219	225	PF00069	0.552
MOD_PKA_2	438	444	PF00069	0.656
MOD_PKA_2	79	85	PF00069	0.502
MOD_PKA_2	87	93	PF00069	0.425
MOD_Plk_1	140	146	PF00069	0.649
MOD_Plk_1	184	190	PF00069	0.551
MOD_Plk_1	234	240	PF00069	0.589
MOD_Plk_1	264	270	PF00069	0.636
MOD_Plk_1	34	40	PF00069	0.464
MOD_Plk_1	44	50	PF00069	0.358
MOD_Plk_4	126	132	PF00069	0.636
MOD_Plk_4	140	146	PF00069	0.548
MOD_Plk_4	159	165	PF00069	0.554
MOD_Plk_4	190	196	PF00069	0.630
MOD_Plk_4	235	241	PF00069	0.608
MOD_Plk_4	303	309	PF00069	0.612
MOD_Plk_4	356	362	PF00069	0.660
MOD_Plk_4	406	412	PF00069	0.630
MOD_Plk_4	44	50	PF00069	0.363
MOD_Plk_4	98	104	PF00069	0.343
MOD_ProDKin_1	80	86	PF00069	0.452
TRG_ENDOCYTIC_2	46	49	PF00928	0.351
TRG_ENDOCYTIC_2	474	477	PF00928	0.533
TRG_NES_CRM1_1	128	139	PF08389	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H581	Leishmania donovani	97%	100%
A0A3S5H583	Leishmania donovani	98%	100%
A0A451EJW1	Leishmania donovani	97%	100%
A0A451EJW4	Leishmania donovani	98%	100%
A0A451EJW6	Leishmania donovani	23%	74%
A4H3T7	Leishmania braziliensis	76%	100%
A4H3T8	Leishmania braziliensis	69%	100%
A4H3T9	Leishmania braziliensis	69%	100%
A4H3U0	Leishmania braziliensis	67%	100%
A4H3U1	Leishmania braziliensis	67%	100%
A4HS14	Leishmania infantum	22%	74%
E9AJZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AK01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	74%
Q9N852	Leishmania major	92%	100%
Q9N853	Leishmania major	92%	100%
Q9N856	Leishmania major	92%	100%
Q9XZX9	Leishmania major	24%	74%