Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A2D1QVA5_LEIDO

TriTrypDb:

LdBPK_282440.1 , LdCL_280029400 , LDHU3_28.3300

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A2D1QVA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A2D1QVA5

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	7
GO:0009889	regulation of biosynthetic process	4	7
GO:0010468	regulation of gene expression	5	7
GO:0010556	regulation of macromolecule biosynthetic process	5	7
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031326	regulation of cellular biosynthetic process	5	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051252	regulation of RNA metabolic process	5	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1903506	regulation of nucleic acid-templated transcription	7	7
GO:2001141	regulation of RNA biosynthetic process	6	7
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004402	histone acetyltransferase activity	4	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0003712	transcription coregulator activity	2	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1
GO:0140110	transcription regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.736
CLV_C14_Caspase3-7	457	461	PF00656	0.821
CLV_C14_Caspase3-7	514	518	PF00656	0.618
CLV_MEL_PAP_1	389	395	PF00089	0.628
CLV_NRD_NRD_1	282	284	PF00675	0.338
CLV_NRD_NRD_1	324	326	PF00675	0.346
CLV_NRD_NRD_1	348	350	PF00675	0.324
CLV_NRD_NRD_1	363	365	PF00675	0.555
CLV_NRD_NRD_1	379	381	PF00675	0.668
CLV_NRD_NRD_1	433	435	PF00675	0.790
CLV_NRD_NRD_1	453	455	PF00675	0.613
CLV_NRD_NRD_1	65	67	PF00675	0.634
CLV_PCSK_FUR_1	63	67	PF00082	0.635
CLV_PCSK_KEX2_1	282	284	PF00082	0.338
CLV_PCSK_KEX2_1	324	326	PF00082	0.346
CLV_PCSK_KEX2_1	348	350	PF00082	0.324
CLV_PCSK_KEX2_1	363	365	PF00082	0.555
CLV_PCSK_KEX2_1	433	435	PF00082	0.790
CLV_PCSK_KEX2_1	455	457	PF00082	0.761
CLV_PCSK_KEX2_1	496	498	PF00082	0.768
CLV_PCSK_KEX2_1	65	67	PF00082	0.599
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.761
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.768
CLV_PCSK_SKI1_1	150	154	PF00082	0.469
CLV_PCSK_SKI1_1	210	214	PF00082	0.336
CLV_PCSK_SKI1_1	217	221	PF00082	0.319
CLV_PCSK_SKI1_1	353	357	PF00082	0.331
CLV_PCSK_SKI1_1	497	501	PF00082	0.758
CLV_PCSK_SKI1_1	543	547	PF00082	0.517
CLV_Separin_Metazoa	575	579	PF03568	0.476
DEG_APCC_DBOX_1	43	51	PF00400	0.616
DEG_APCC_DBOX_1	64	72	PF00400	0.606
DEG_ODPH_VHL_1	403	416	PF01847	0.578
DEG_SPOP_SBC_1	491	495	PF00917	0.742
DEG_SPOP_SBC_1	510	514	PF00917	0.509
DOC_ANK_TNKS_1	178	185	PF00023	0.527
DOC_ANK_TNKS_1	432	439	PF00023	0.789
DOC_CYCLIN_RxL_1	205	218	PF00134	0.546
DOC_MAPK_gen_1	363	370	PF00069	0.584
DOC_MAPK_gen_1	496	502	PF00069	0.759
DOC_PP1_RVXF_1	565	572	PF00149	0.488
DOC_PP2B_LxvP_1	180	183	PF13499	0.494
DOC_PP2B_LxvP_1	562	565	PF13499	0.500
DOC_PP4_FxxP_1	153	156	PF00568	0.436
DOC_USP7_MATH_1	12	16	PF00917	0.623
DOC_USP7_MATH_1	121	125	PF00917	0.768
DOC_USP7_MATH_1	136	140	PF00917	0.474
DOC_USP7_MATH_1	293	297	PF00917	0.697
DOC_USP7_MATH_1	298	302	PF00917	0.574
DOC_USP7_MATH_1	491	495	PF00917	0.742
DOC_USP7_MATH_1	510	514	PF00917	0.509
DOC_USP7_UBL2_3	377	381	PF12436	0.820
DOC_WW_Pin1_4	327	332	PF00397	0.546
DOC_WW_Pin1_4	505	510	PF00397	0.825
DOC_WW_Pin1_4	52	57	PF00397	0.710
DOC_WW_Pin1_4	78	83	PF00397	0.542
LIG_14-3-3_CanoR_1	160	166	PF00244	0.483
LIG_14-3-3_CanoR_1	193	198	PF00244	0.501
LIG_14-3-3_CanoR_1	282	290	PF00244	0.787
LIG_14-3-3_CanoR_1	44	54	PF00244	0.571
LIG_14-3-3_CanoR_1	476	486	PF00244	0.834
LIG_14-3-3_CanoR_1	553	560	PF00244	0.553
LIG_14-3-3_CanoR_1	80	86	PF00244	0.522
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_3	1	5	PF00653	0.611
LIG_BIR_III_4	135	139	PF00653	0.689
LIG_eIF4E_1	101	107	PF01652	0.489
LIG_eIF4E_1	70	76	PF01652	0.577
LIG_FHA_1	123	129	PF00498	0.682
LIG_FHA_1	487	493	PF00498	0.753
LIG_FHA_2	439	445	PF00498	0.751
LIG_FHA_2	461	467	PF00498	0.820
LIG_FHA_2	524	530	PF00498	0.636
LIG_LIR_Apic_2	151	156	PF02991	0.444
LIG_LIR_Gen_1	163	170	PF02991	0.471
LIG_LIR_Gen_1	48	59	PF02991	0.577
LIG_LIR_Gen_1	570	577	PF02991	0.466
LIG_LIR_Nem_3	48	54	PF02991	0.691
LIG_LIR_Nem_3	84	90	PF02991	0.468
LIG_NRBOX	541	547	PF00104	0.509
LIG_Pex14_2	153	157	PF04695	0.389
LIG_Pex14_2	256	260	PF04695	0.506
LIG_PTB_Apo_2	105	112	PF02174	0.623
LIG_PTB_Apo_2	228	235	PF02174	0.574
LIG_PTB_Phospho_1	105	111	PF10480	0.621
LIG_Rb_pABgroove_1	567	575	PF01858	0.468
LIG_SH2_GRB2like	90	93	PF00017	0.472
LIG_SH2_NCK_1	319	323	PF00017	0.546
LIG_SH2_STAP1	162	166	PF00017	0.595
LIG_SH2_STAP1	319	323	PF00017	0.546
LIG_SH2_STAP1	573	577	PF00017	0.489
LIG_SH2_STAT5	208	211	PF00017	0.546
LIG_SH2_STAT5	233	236	PF00017	0.531
LIG_SH2_STAT5	243	246	PF00017	0.488
LIG_SH2_STAT5	247	250	PF00017	0.458
LIG_SH2_STAT5	255	258	PF00017	0.383
LIG_SH2_STAT5	568	571	PF00017	0.478
LIG_SH2_STAT5	70	73	PF00017	0.591
LIG_SH2_STAT5	87	90	PF00017	0.455
LIG_SH2_STAT5	94	97	PF00017	0.485
LIG_SH3_1	286	292	PF00018	0.633
LIG_SH3_1	399	405	PF00018	0.619
LIG_SH3_3	110	116	PF00018	0.562
LIG_SH3_3	286	292	PF00018	0.678
LIG_SH3_3	301	307	PF00018	0.276
LIG_SH3_3	328	334	PF00018	0.546
LIG_SH3_3	399	405	PF00018	0.650
LIG_SH3_3	584	590	PF00018	0.441
LIG_SH3_3	92	98	PF00018	0.487
LIG_SUMO_SIM_anti_2	413	421	PF11976	0.679
LIG_SUMO_SIM_par_1	413	421	PF11976	0.678
LIG_TRAF2_1	11	14	PF00917	0.578
LIG_TRAF2_1	183	186	PF00917	0.534
LIG_UBA3_1	212	217	PF00899	0.546
LIG_WW_3	302	306	PF00397	0.450
MOD_CDK_SPxK_1	327	333	PF00069	0.546
MOD_CK1_1	249	255	PF00069	0.546
MOD_CK1_1	394	400	PF00069	0.786
MOD_CK1_1	432	438	PF00069	0.787
MOD_CK1_1	595	601	PF00069	0.706
MOD_CK2_1	215	221	PF00069	0.516
MOD_CK2_1	438	444	PF00069	0.814
MOD_CK2_1	460	466	PF00069	0.822
MOD_CK2_1	578	584	PF00069	0.544
MOD_Cter_Amidation	280	283	PF01082	0.346
MOD_GlcNHglycan	13	17	PF01048	0.703
MOD_GlcNHglycan	19	22	PF01048	0.656
MOD_GlcNHglycan	250	254	PF01048	0.346
MOD_GlcNHglycan	396	399	PF01048	0.837
MOD_GlcNHglycan	408	411	PF01048	0.680
MOD_GlcNHglycan	424	427	PF01048	0.577
MOD_GlcNHglycan	434	437	PF01048	0.739
MOD_GlcNHglycan	451	454	PF01048	0.562
MOD_GlcNHglycan	5	8	PF01048	0.668
MOD_GlcNHglycan	502	505	PF01048	0.812
MOD_GSK3_1	12	19	PF00069	0.681
MOD_GSK3_1	200	207	PF00069	0.512
MOD_GSK3_1	294	301	PF00069	0.692
MOD_GSK3_1	416	423	PF00069	0.722
MOD_GSK3_1	456	463	PF00069	0.833
MOD_GSK3_1	486	493	PF00069	0.772
MOD_GSK3_1	505	512	PF00069	0.669
MOD_GSK3_1	519	526	PF00069	0.565
MOD_GSK3_1	595	602	PF00069	0.711
MOD_N-GLC_1	200	205	PF02516	0.346
MOD_NEK2_1	355	360	PF00069	0.546
MOD_NEK2_1	486	491	PF00069	0.755
MOD_NEK2_1	492	497	PF00069	0.670
MOD_NEK2_1	500	505	PF00069	0.580
MOD_NEK2_1	58	63	PF00069	0.552
MOD_NEK2_1	592	597	PF00069	0.576
MOD_NEK2_2	438	443	PF00069	0.753
MOD_PIKK_1	200	206	PF00454	0.546
MOD_PIKK_1	519	525	PF00454	0.716
MOD_PIKK_1	58	64	PF00454	0.598
MOD_PKA_1	282	288	PF00069	0.786
MOD_PKA_1	325	331	PF00069	0.574
MOD_PKA_1	454	460	PF00069	0.753
MOD_PKA_2	281	287	PF00069	0.763
MOD_PKA_2	391	397	PF00069	0.833
MOD_PKA_2	432	438	PF00069	0.766
MOD_PKA_2	523	529	PF00069	0.556
MOD_PKA_2	552	558	PF00069	0.558
MOD_PKA_2	595	601	PF00069	0.706
MOD_PKB_1	454	462	PF00069	0.646
MOD_Plk_1	12	18	PF00069	0.689
MOD_Plk_1	249	255	PF00069	0.475
MOD_Plk_1	420	426	PF00069	0.755
MOD_Plk_1	579	585	PF00069	0.493
MOD_Plk_2-3	460	466	PF00069	0.822
MOD_Plk_4	193	199	PF00069	0.534
MOD_Plk_4	215	221	PF00069	0.546
MOD_Plk_4	90	96	PF00069	0.475
MOD_ProDKin_1	327	333	PF00069	0.546
MOD_ProDKin_1	505	511	PF00069	0.825
MOD_ProDKin_1	52	58	PF00069	0.706
MOD_ProDKin_1	78	84	PF00069	0.533
MOD_SUMO_for_1	461	464	PF00179	0.841
MOD_SUMO_rev_2	218	225	PF00179	0.546
MOD_SUMO_rev_2	373	383	PF00179	0.748
MOD_SUMO_rev_2	431	441	PF00179	0.789
MOD_SUMO_rev_2	457	463	PF00179	0.847
TRG_DiLeu_BaEn_4	13	19	PF01217	0.501
TRG_DiLeu_BaEn_4	537	543	PF01217	0.507
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.573
TRG_ENDOCYTIC_2	101	104	PF00928	0.462
TRG_ENDOCYTIC_2	111	114	PF00928	0.544
TRG_ENDOCYTIC_2	165	168	PF00928	0.471
TRG_ENDOCYTIC_2	233	236	PF00928	0.546
TRG_ENDOCYTIC_2	343	346	PF00928	0.576
TRG_ENDOCYTIC_2	51	54	PF00928	0.598
TRG_ENDOCYTIC_2	573	576	PF00928	0.467
TRG_ER_diArg_1	179	182	PF00400	0.501
TRG_ER_diArg_1	286	289	PF00400	0.655
TRG_ER_diArg_1	323	325	PF00400	0.546
TRG_ER_diArg_1	347	349	PF00400	0.524
TRG_ER_diArg_1	362	364	PF00400	0.538
TRG_ER_diArg_1	63	66	PF00400	0.633
TRG_NLS_MonoExtN_4	451	458	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIW1	Leptomonas seymouri	61%	81%
A4HGT1	Leishmania braziliensis	79%	100%
A4I3V8	Leishmania infantum	100%	100%
E9B048	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q837	Leishmania major	95%	100%