Cyclin, N-terminal domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin 9, putative

Species:

Leishmania donovani

UniProt:

A0A2D1QVA3_LEIDO

TriTrypDb:

LdBPK_320800.1 , LdCL_320013600 , LDHU3_32.1000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A2D1QVA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A2D1QVA3

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	11
GO:0009889	regulation of biosynthetic process	4	11
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051252	regulation of RNA metabolic process	5	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:2001141	regulation of RNA biosynthetic process	6	11
GO:0010564	regulation of cell cycle process	5	1
GO:0032465	regulation of cytokinesis	5	1
GO:0051302	regulation of cell division	4	1
GO:0051726	regulation of cell cycle	4	1
GO:1902412	regulation of mitotic cytokinesis	6	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	11
GO:0019207	kinase regulator activity	3	11
GO:0019887	protein kinase regulator activity	4	11
GO:0030234	enzyme regulator activity	2	11
GO:0098772	molecular function regulator activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.480
CLV_NRD_NRD_1	207	209	PF00675	0.521
CLV_NRD_NRD_1	28	30	PF00675	0.572
CLV_NRD_NRD_1	45	47	PF00675	0.372
CLV_NRD_NRD_1	71	73	PF00675	0.379
CLV_PCSK_FUR_1	261	265	PF00082	0.470
CLV_PCSK_KEX2_1	174	176	PF00082	0.480
CLV_PCSK_KEX2_1	207	209	PF00082	0.521
CLV_PCSK_KEX2_1	263	265	PF00082	0.498
CLV_PCSK_KEX2_1	28	30	PF00082	0.500
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.491
CLV_PCSK_SKI1_1	122	126	PF00082	0.413
CLV_PCSK_SKI1_1	174	178	PF00082	0.372
DOC_CKS1_1	181	186	PF01111	0.368
DOC_CYCLIN_yClb3_PxF_3	21	29	PF00134	0.621
DOC_MAPK_gen_1	46	56	PF00069	0.376
DOC_MAPK_gen_1	72	79	PF00069	0.323
DOC_MAPK_MEF2A_6	122	131	PF00069	0.403
DOC_PP4_FxxP_1	18	21	PF00568	0.671
DOC_PP4_FxxP_1	181	184	PF00568	0.334
DOC_PP4_FxxP_1	249	252	PF00568	0.504
DOC_USP7_MATH_1	213	217	PF00917	0.537
DOC_USP7_MATH_1	8	12	PF00917	0.611
DOC_WW_Pin1_4	1	6	PF00397	0.635
DOC_WW_Pin1_4	180	185	PF00397	0.366
DOC_WW_Pin1_4	285	290	PF00397	0.571
DOC_WW_Pin1_4	9	14	PF00397	0.580
LIG_14-3-3_CanoR_1	150	156	PF00244	0.542
LIG_14-3-3_CanoR_1	193	202	PF00244	0.424
LIG_14-3-3_CanoR_1	32	40	PF00244	0.488
LIG_14-3-3_CanoR_1	49	56	PF00244	0.447
LIG_Actin_WH2_2	135	152	PF00022	0.495
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BRCT_BRCA1_1	14	18	PF00533	0.693
LIG_BRCT_BRCA1_1	276	280	PF00533	0.697
LIG_BRCT_BRCA1_1	283	287	PF00533	0.680
LIG_FHA_1	194	200	PF00498	0.443
LIG_FHA_1	233	239	PF00498	0.457
LIG_FHA_1	49	55	PF00498	0.432
LIG_FHA_1	79	85	PF00498	0.447
LIG_FHA_2	152	158	PF00498	0.552
LIG_LIR_Apic_2	15	21	PF02991	0.656
LIG_LIR_Apic_2	180	184	PF02991	0.344
LIG_LIR_Apic_2	216	221	PF02991	0.506
LIG_LIR_Gen_1	134	145	PF02991	0.502
LIG_LIR_Gen_1	197	206	PF02991	0.475
LIG_LIR_Gen_1	212	221	PF02991	0.531
LIG_LIR_Gen_1	240	249	PF02991	0.499
LIG_LIR_Nem_3	134	140	PF02991	0.502
LIG_LIR_Nem_3	197	203	PF02991	0.464
LIG_LIR_Nem_3	212	217	PF02991	0.440
LIG_LIR_Nem_3	240	245	PF02991	0.487
LIG_LIR_Nem_3	27	33	PF02991	0.499
LIG_LIR_Nem_3	284	290	PF02991	0.681
LIG_OCRL_FandH_1	241	253	PF00620	0.505
LIG_Pex14_2	139	143	PF04695	0.509
LIG_Pex14_2	177	181	PF04695	0.331
LIG_Pex14_2	214	218	PF04695	0.521
LIG_SH2_CRK	200	204	PF00017	0.510
LIG_SH2_SRC	22	25	PF00017	0.644
LIG_SH2_STAT5	22	25	PF00017	0.589
LIG_SH2_STAT5	244	247	PF00017	0.485
LIG_SH2_STAT5	30	33	PF00017	0.397
LIG_SH2_STAT5	43	46	PF00017	0.270
LIG_SH3_3	18	24	PF00018	0.644
LIG_SH3_3	2	8	PF00018	0.635
LIG_SUMO_SIM_anti_2	126	131	PF11976	0.496
LIG_SUMO_SIM_par_1	123	128	PF11976	0.488
LIG_TRAF2_1	165	168	PF00917	0.553
LIG_TYR_ITIM	198	203	PF00017	0.466
LIG_WRC_WIRS_1	178	183	PF05994	0.348
LIG_WRC_WIRS_1	23	28	PF05994	0.580
MOD_CDK_SPxxK_3	285	292	PF00069	0.687
MOD_CK1_1	12	18	PF00069	0.619
MOD_CK1_1	151	157	PF00069	0.546
MOD_CK1_1	180	186	PF00069	0.368
MOD_CK1_1	216	222	PF00069	0.574
MOD_CK1_1	278	284	PF00069	0.599
MOD_CK1_1	3	9	PF00069	0.678
MOD_CK2_1	151	157	PF00069	0.546
MOD_CK2_1	216	222	PF00069	0.518
MOD_GlcNHglycan	218	221	PF01048	0.536
MOD_GlcNHglycan	281	284	PF01048	0.610
MOD_GlcNHglycan	35	38	PF01048	0.501
MOD_GSK3_1	209	216	PF00069	0.495
MOD_GSK3_1	274	281	PF00069	0.612
MOD_GSK3_1	4	11	PF00069	0.619
MOD_GSK3_1	50	57	PF00069	0.354
MOD_N-GLC_1	109	114	PF02516	0.479
MOD_NEK2_1	131	136	PF00069	0.398
MOD_NEK2_1	145	150	PF00069	0.372
MOD_NEK2_1	177	182	PF00069	0.347
MOD_NEK2_1	194	199	PF00069	0.346
MOD_NEK2_1	201	206	PF00069	0.481
MOD_NEK2_1	31	36	PF00069	0.505
MOD_NEK2_1	50	55	PF00069	0.150
MOD_NEK2_1	79	84	PF00069	0.340
MOD_PIKK_1	264	270	PF00454	0.633
MOD_PIKK_1	31	37	PF00454	0.488
MOD_PKA_2	31	37	PF00069	0.488
MOD_PKA_2	48	54	PF00069	0.447
MOD_Plk_4	194	200	PF00069	0.439
MOD_Plk_4	213	219	PF00069	0.518
MOD_Plk_4	275	281	PF00069	0.667
MOD_Plk_4	50	56	PF00069	0.352
MOD_ProDKin_1	1	7	PF00069	0.633
MOD_ProDKin_1	180	186	PF00069	0.368
MOD_ProDKin_1	285	291	PF00069	0.570
MOD_ProDKin_1	9	15	PF00069	0.579
MOD_SUMO_for_1	88	91	PF00179	0.447
TRG_ENDOCYTIC_2	200	203	PF00928	0.471
TRG_ENDOCYTIC_2	30	33	PF00928	0.440
TRG_ER_diArg_1	173	175	PF00400	0.485
TRG_ER_diArg_1	28	30	PF00400	0.500
TRG_NES_CRM1_1	133	147	PF08389	0.459
TRG_NES_CRM1_1	230	240	PF08389	0.497
TRG_NLS_Bipartite_1	247	267	PF00514	0.441
TRG_NLS_Bipartite_1	28	50	PF00514	0.362
TRG_NLS_MonoExtN_4	261	267	PF00514	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK2	Leptomonas seymouri	77%	100%
A0A1X0NWC7	Trypanosomatidae	33%	100%
A0A422N086	Trypanosoma rangeli	35%	100%
A4HK57	Leishmania braziliensis	93%	100%
A4I7P3	Leishmania infantum	100%	100%
D0A9U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B2K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q5K6	Leishmania major	95%	100%
V5BFB1	Trypanosoma cruzi	35%	100%