DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania donovani

UniProt:

A0A0R6XPC0_LEIDO

TriTrypDb:

LdBPK_101390.1 , LdCL_100021100 , LDHU3_10.1770

Length:

318

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A0R6XPC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A0R6XPC0

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.330
CLV_C14_Caspase3-7	311	315	PF00656	0.464
CLV_C14_Caspase3-7	96	100	PF00656	0.216
CLV_NRD_NRD_1	109	111	PF00675	0.367
CLV_PCSK_KEX2_1	59	61	PF00082	0.374
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.383
CLV_PCSK_SKI1_1	115	119	PF00082	0.339
CLV_PCSK_SKI1_1	25	29	PF00082	0.416
DOC_CYCLIN_RxL_1	21	29	PF00134	0.370
DOC_MAPK_gen_1	6	14	PF00069	0.451
DOC_PP1_RVXF_1	9	15	PF00149	0.424
DOC_PP4_FxxP_1	157	160	PF00568	0.342
DOC_USP7_MATH_1	273	277	PF00917	0.337
DOC_USP7_MATH_1	93	97	PF00917	0.384
DOC_USP7_UBL2_3	261	265	PF12436	0.342
DOC_WW_Pin1_4	177	182	PF00397	0.236
DOC_WW_Pin1_4	260	265	PF00397	0.299
LIG_14-3-3_CanoR_1	115	120	PF00244	0.353
LIG_14-3-3_CanoR_1	159	168	PF00244	0.342
LIG_AP2alpha_2	92	94	PF02296	0.361
LIG_APCC_ABBA_1	68	73	PF00400	0.326
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_BRCT_BRCA1_1	41	45	PF00533	0.350
LIG_FHA_1	178	184	PF00498	0.335
LIG_FHA_2	134	140	PF00498	0.354
LIG_FHA_2	180	186	PF00498	0.309
LIG_FHA_2	309	315	PF00498	0.360
LIG_FHA_2	72	78	PF00498	0.344
LIG_IBAR_NPY_1	241	243	PF08397	0.224
LIG_LIR_Gen_1	118	128	PF02991	0.343
LIG_LIR_Gen_1	2	12	PF02991	0.383
LIG_LIR_Gen_1	216	225	PF02991	0.349
LIG_LIR_Gen_1	234	244	PF02991	0.456
LIG_LIR_Gen_1	66	72	PF02991	0.341
LIG_LIR_Gen_1	77	87	PF02991	0.364
LIG_LIR_Nem_3	118	123	PF02991	0.371
LIG_LIR_Nem_3	195	201	PF02991	0.338
LIG_LIR_Nem_3	2	7	PF02991	0.439
LIG_LIR_Nem_3	216	221	PF02991	0.355
LIG_LIR_Nem_3	231	236	PF02991	0.353
LIG_LIR_Nem_3	287	292	PF02991	0.333
LIG_LIR_Nem_3	29	33	PF02991	0.368
LIG_LIR_Nem_3	51	57	PF02991	0.369
LIG_LIR_Nem_3	66	70	PF02991	0.337
LIG_LIR_Nem_3	77	82	PF02991	0.361
LIG_PCNA_yPIPBox_3	110	120	PF02747	0.342
LIG_PDZ_Class_2	313	318	PF00595	0.416
LIG_Pex14_1	63	67	PF04695	0.270
LIG_PTB_Apo_2	232	239	PF02174	0.344
LIG_REV1ctd_RIR_1	121	129	PF16727	0.299
LIG_SH2_CRK	236	240	PF00017	0.353
LIG_SH2_CRK	289	293	PF00017	0.342
LIG_SH2_GRB2like	233	236	PF00017	0.342
LIG_SH2_PTP2	67	70	PF00017	0.323
LIG_SH2_STAP1	23	27	PF00017	0.350
LIG_SH2_STAP1	236	240	PF00017	0.329
LIG_SH2_STAT5	120	123	PF00017	0.348
LIG_SH2_STAT5	133	136	PF00017	0.332
LIG_SH2_STAT5	205	208	PF00017	0.352
LIG_SH2_STAT5	220	223	PF00017	0.312
LIG_SH2_STAT5	233	236	PF00017	0.342
LIG_SH2_STAT5	243	246	PF00017	0.345
LIG_SH2_STAT5	67	70	PF00017	0.356
LIG_SH3_3	236	242	PF00018	0.342
LIG_TRFH_1	238	242	PF08558	0.342
LIG_TRFH_1	79	83	PF08558	0.286
LIG_TYR_ITSM	232	239	PF00017	0.363
LIG_WRC_WIRS_1	1	6	PF05994	0.481
LIG_WRC_WIRS_1	27	32	PF05994	0.362
MOD_CDK_SPK_2	260	265	PF00069	0.351
MOD_CK1_1	132	138	PF00069	0.318
MOD_CK1_1	216	222	PF00069	0.395
MOD_CK2_1	179	185	PF00069	0.385
MOD_GlcNHglycan	275	278	PF01048	0.345
MOD_GlcNHglycan	289	292	PF01048	0.342
MOD_GlcNHglycan	41	44	PF01048	0.481
MOD_GSK3_1	129	136	PF00069	0.301
MOD_GSK3_1	155	162	PF00069	0.349
MOD_N-GLC_1	129	134	PF02516	0.223
MOD_N-GLC_1	234	239	PF02516	0.359
MOD_N-GLC_1	39	44	PF02516	0.346
MOD_NEK2_1	104	109	PF00069	0.340
MOD_NEK2_1	71	76	PF00069	0.347
MOD_NEK2_2	26	31	PF00069	0.243
MOD_PKA_2	109	115	PF00069	0.297
MOD_PKA_2	124	130	PF00069	0.383
MOD_PKA_2	298	304	PF00069	0.352
MOD_Plk_1	129	135	PF00069	0.320
MOD_Plk_1	228	234	PF00069	0.342
MOD_Plk_1	77	83	PF00069	0.359
MOD_Plk_4	129	135	PF00069	0.362
MOD_Plk_4	179	185	PF00069	0.344
MOD_Plk_4	216	222	PF00069	0.368
MOD_Plk_4	234	240	PF00069	0.337
MOD_Plk_4	308	314	PF00069	0.418
MOD_Plk_4	63	69	PF00069	0.301
MOD_ProDKin_1	177	183	PF00069	0.236
MOD_ProDKin_1	260	266	PF00069	0.299
MOD_SUMO_for_1	45	48	PF00179	0.210
MOD_SUMO_for_1	7	10	PF00179	0.386
MOD_SUMO_rev_2	5	12	PF00179	0.446
TRG_DiLeu_BaEn_4	185	191	PF01217	0.342
TRG_ENDOCYTIC_2	120	123	PF00928	0.395
TRG_ENDOCYTIC_2	218	221	PF00928	0.358
TRG_ENDOCYTIC_2	236	239	PF00928	0.382
TRG_ENDOCYTIC_2	289	292	PF00928	0.342
TRG_ENDOCYTIC_2	67	70	PF00928	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	64%	100%
A0A0N1HYU8	Leptomonas seymouri	87%	100%
A0A0N1I429	Leptomonas seymouri	54%	97%
A0A0N1I5D6	Leptomonas seymouri	56%	100%
A0A0N1I720	Leptomonas seymouri	56%	100%
A0A0N1IL04	Leptomonas seymouri	56%	100%
A0A0N1PCE9	Leptomonas seymouri	51%	99%
A0A3Q8IHB3	Leishmania donovani	48%	99%
A0A3S5H6H4	Leishmania donovani	54%	97%
A0A3S5H6H5	Leishmania donovani	53%	100%
A0A3S7WRC9	Leishmania donovani	64%	100%
A0A3S7WRD5	Leishmania donovani	60%	100%
A0A3S7WRE8	Leishmania donovani	54%	100%
A4H6B5	Leishmania braziliensis	51%	100%
A4H6B6	Leishmania braziliensis	48%	100%
A4H6B7	Leishmania braziliensis	91%	100%
A4H6B8	Leishmania braziliensis	58%	100%
A4H6B9	Leishmania braziliensis	53%	100%
A4H6C0	Leishmania braziliensis	63%	99%
A4H6C1	Leishmania braziliensis	55%	100%
A4HUN8	Leishmania infantum	54%	100%
A4HUN9	Leishmania infantum	48%	100%
A4HUP0	Leishmania infantum	100%	100%
A4HUP1	Leishmania infantum	60%	100%
A4HUP2	Leishmania infantum	53%	100%
A4HUP3	Leishmania infantum	64%	99%
A4HUP4	Leishmania infantum	54%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	99%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
Q4QH83	Leishmania major	54%	100%
Q4QH84	Leishmania major	64%	99%
Q4QH85	Leishmania major	53%	100%
Q4QH86	Leishmania major	59%	100%
Q4QH87	Leishmania major	97%	100%
Q4QH88	Leishmania major	49%	100%
Q4QH89	Leishmania major	56%	100%